PMID: 19916931Nov 18, 2009Paper

Inhibition of C5-cytosine-DNA-methyltransferases

Biochemistry. Biokhimii︠a︡
Olga V KirsanovaE S Gromova

Abstract

Changes in the methylation pattern of genomic DNA, particularly hypermethylation of tumor suppressor genes, occur at early stages of tumor development. Errors in DNA methylation contribute to both initiation and progression of various cancers. This stimulates significant interest in searching for inhibitors of C5-DNA-methyltransferases (MTases). Here we review the known nucleoside mechanism-based reversible and irreversible inhibitors of the MTases, as well as non-nucleoside ones, and discuss their inhibitory mechanisms and application for MTase investigations and cancer therapy.

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Citations

Nov 17, 2010·Biochemistry. Biokhimii︠a︡·N A CherepanovaE S Gromova
Jul 10, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·N A CherepanovaE S Gromova
Apr 12, 2021·Biochemistry. Biokhimii︠a︡·Dariya A KhrabrovaElizaveta S Gromova

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