PMID: 2493242Jan 1, 1989Paper

Inhibition of Ca2+-induced cytosolic enzyme efflux from skeletal muscle by vitamin E and related compounds

The Biochemical Journal
J PhoenixM J Jackson

Abstract

1. Efflux of an intracellular enzyme (creatine kinase) from normal rat skeletal muscles was induced by treatment with the Ca2+ ionophore A23187. Addition of alpha-tocopherol (230 microM) to the incubation medium was found to significantly diminish this efflux, and this effect was mimicked by alpha-tocopherol acetate, phytol and isophytol, but not by Trolox C (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid). 2. Analysis of muscle cation content has shown that these protective effects of alpha-tocopherol etc. are not due to an inhibition of the Ca2+ accumulating effects of the ionophore. 3. Non-enzymic lipid peroxidation of skeletal-muscle homogenates was found to be inhibited by alpha-tocopherol and Trolox C, partially inhibited by phytol and isophytol, but unaffected by alpha-tocopherol acetate. 4. The activity of lipoxygenase enzymes was partially inhibited by alpha-tocopherol, phytol and isophytol, but not by alpha-tocopherol acetate or Trolox C. 5. Prostaglandin E2 efflux from isolated skeletal muscles was stimulated by treatment with the Ca2+ ionophore, but this was unaffected by alpha-tocopherol treatment.

Citations

Jan 1, 1991·Free Radical Research Communications·D K BowlesJ W Starnes
Mar 20, 2010·Critical Reviews in Food Science and Nutrition·Neal Okarter, Rui Hai Liu
Jun 11, 1999·Japanese Journal of Cancer Research : Gann·M KagouraM Morohashi
Oct 1, 1991·Pflügers Archiv : European journal of physiology·G J AmelinkP R Bär
Feb 1, 1990·The Proceedings of the Nutrition Society·M J Jackson
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·P Jakeman, S Maxwell
May 1, 1994·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·V A CwikM H Brooke
Sep 18, 1997·Journal of Applied Physiology·J H Van Der MeulenJ A Faulkner
Jul 1, 1990·The British Journal of Nutrition·J PhoenixM J Jackson
Jan 1, 1998·Nutritional Neuroscience·M J Fryer
Aug 21, 2019·Current Osteoporosis Reports·Jianfeng JinRichard T Jaspers
Oct 1, 1992·Free Radical Biology & Medicine·G Barja de Quiroga
Jul 8, 1991·Biochimica Et Biophysica Acta·W SakamotoM Mino

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