Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats

Neuroscience Letters
Zhuo LiuLong-Chuan Yu

Abstract

The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) may be a core component in the common molecular pathways for drug addiction. Moreover, studies using animal models of drug addiction have demonstrated that changing CaMKII activity or expression influences animals' responses to the drugs of abuse. Here, we explored the roles of CaMKII in the nucleus accumbens (NAc) shell in the extinction and reinstatement of morphine-seeking behavior. Rats were trained to obtain intravenous morphine infusions through poking hole on a fixed-ratio one schedule. Selective CaMKII inhibitor myristoylated autocamtide-2-inhibitory peptide (myr-AIP) was injected into the NAc shell of rats after the acquisition of morphine self-administration (SA) or before the reinstatement test. The results demonstrated that injection of myr-AIP after acquisition of morphine SA did not influence morphine-seeking in the following extinction days and the number of days spent for reaching extinction criterion. However, pretreatment with myr-AIP before the reinstatement test blocked the reinstatement of morphine-seeking behavior induced by morphine-priming. Our results strongly indicate that CaMKII activity in the NAc shell is essential to the relapse to morphine...Continue Reading

References

Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·A J SilvaS Tonegawa
Jul 26, 1995·Biochemical and Biophysical Research Communications·A IshidaH Fujisawa
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·F E PontieriG Di Chiara
Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Hedayat SahraeiMohammad Reza Zarrindast
Oct 7, 2004·Learning & Memory·Mark E Bouton
Mar 15, 2005·Stress : the International Journal on the Biology of Stress·David W Self, Kwang-Ho Choi
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharon M AndersonR Christopher Pierce
Oct 20, 2007·Neuroscience Letters·Seong Shoon YoonChae Ha Yang
Jan 9, 2008·PLoS Computational Biology·Chuan-Yun LiLiping Wei
Feb 19, 2008·Nature Neuroscience·Sharon M AndersonR Christopher Pierce
Nov 11, 2008·Annals of the New York Academy of Sciences·Anna M Lee, Robert O Messing
Jan 23, 2009·Nature Neuroscience·Michel C Van den OeverTaco J De Vries
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lei WangLan Ma
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica A LowethPaul Vezina
Feb 16, 2010·Learning & Memory·Orit Holtzman-AssifR Frederick Westbrook
Apr 27, 2011·Psychopharmacology·Giovanni Hernandez, Joseph F Cheer

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Citations

May 4, 2013·Neuropharmacology·Cassandra D GipsonPeter W Kalivas
Oct 22, 2013·Pharmacology, Biochemistry, and Behavior·Boris Tabakoff, Paula L Hoffman
Sep 30, 2014·Peptides·Richard J Bodnar
Dec 18, 2015·Trends in Pharmacological Sciences·Christian P MüllerK Peter Giese
Jul 16, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura G RosenSteven R Laviolette
Apr 9, 2016·European Journal of Pharmacology·García-Pardo María PilarAguilar María Asunción
Nov 21, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Timothy J O'NealSusan M Ferguson
Jul 9, 2021·Pharmacological Reports : PR·Małgorzata FrankowskaPatrycja Kleczkowska

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