Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles

Journal of Biomedical Nanotechnology
Cheng WangWei Xu

Abstract

Tumor-associated angiogenesis is triggered by multiple angiogenic factors. Vascular endothelial growth factor blockers are currently a major mechanism of angiogenesis inhibition; however, either insensitivity due to the targeting of single angiogenic factors or serious side effects due to non-specific exposure ultimately leads to the failure of treatment. The herb-derived compound triptolide (TP) can inhibit tumor growth through multiple mechanisms. However, its hydrophobicity and side effects have hindered its translation to the clinic. Here, we have prepared TP-polymeric micelles (TP-PMs) using methoxy poly(ethylene glycol)-block-poly(ε-caprolactone). The drug loading efficiency and encapsulation efficiency can reach 7.2 ± 0.10% and 99.1 ± 1.05%, respectively. The TP-PM solution consisted of monodispersed particles (PDI = 0.100 ± 0.023), which were 53.1 ± 1.2 nm in size. In vitro release profiles indicated that the TP-PM solution exhibited better sustained-release action when compared with free TP solution. Pharmacokinetic and tumor tissue distribution studies showed that TP-PMs facilitated TP accumulation in tumor tissues. The tumor inhibition rate upon treatment with TP-PMs was higher than 50%, and the survival time of B16-...Continue Reading

Citations

Feb 25, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Geng WangYafang Zhang
Mar 25, 2017·International Journal of Cancer. Journal International Du Cancer·Jian-Qin TangGuan Jiang
Jan 15, 2016·International Journal of Pharmaceutics·Bo ZhuangHuashi Guan
Apr 21, 2016·Natural Products and Bioprospecting·Wen-Dan XuHong-Bo Qin
Aug 14, 2020·Drug Delivery and Translational Research·Juliana Santos Rosa ViegasMaria Vitoria Lopes Badra Bentley
Aug 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao WeiMeidong Lang
Jan 24, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qing RenJun Lu

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