Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis

Laboratory Investigation; a Journal of Technical Methods and Pathology
Yukinari MasudaYuh Fukuda

Abstract

The pathological process of glomerulonephritis (GN) includes glomerular capillary damage, and vascular endothelial growth factor (VEGF) has an important role in glomerular capillary repair in GN. We examined the effect of inhibition of glomerular capillary repair after capillary injury in GN. Experimental Thy-1 GN was induced in rats that were divided into two groups: rats that received anti-VEGF neutralizing antibody (50 μg per 100 g body weight per day) and those treated with the vehicle from day 2 to day 9. We assessed the renal function and histopathology serially until week 6. Rats of the Thy-1 GN group showed diffuse glomerular mesangiolysis with ballooning destruction of the capillary network by day 3. VEGF(164) protein levels increased in the damaged glomeruli during days 5 to 10, and endothelial-cell proliferation increased with capillary repair in the vehicle-injected group. Proliferative GN resolved subsequently with decreased mesangial hypercellularity, and recovery of most of the glomeruli to the normal structure was evident by week 6. In contrast, administration of anti-VEGF antibody significantly decreased endothelial-cell proliferation and capillary repair in glomeruli by week 2. Thereafter, glomerular mesangial...Continue Reading

References

May 6, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B KlankeH J Gröne
Jun 3, 1999·Kidney & Blood Pressure Research·N Yamanaka, A Shimizu
Oct 8, 1999·The Journal of Clinical Investigation·T OstendorfJ Floege
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Ryuji OhashiNobuaki Yamanaka
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·An S DE VrieseNorbert H Lameire
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Sep 5, 2001·Kidney International·J A JeffersonW G Couser
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Ryuji OhashiNobuaki Yamanaka
Dec 24, 2002·Current Opinion in Nephrology and Hypertension·Duk-Hee Kang, Richard J Johnson
May 20, 2004·Kidney International·Bieke F SchrijversAn S De Vriese
Jun 18, 2005·Biochemical and Biophysical Research Communications·Napoleone FerraraWilliam Novotny
Jan 27, 2006·Journal of the American Society of Nephrology : JASN·Vera EreminaSusan E Quaggin
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xiaolei ZhuChirag R Parikh
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian I Rini
Jul 10, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tammo OstendorfJürgen Floege
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Isaac E Stillman, S Ananth Karumanchi
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hassane IzzedineGilbert Deray
Sep 25, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E KapiteijnH Gelderblom
Mar 14, 2008·The New England Journal of Medicine·Vera EreminaSusan E Quaggin
Jun 13, 2008·Kidney International·M Barry StokesVivette D D'Agati
Jul 19, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Peter van Wijngaarden, Salmaan H Qureshi
Apr 4, 2009·Anti-cancer Drugs·Vincent Launay-Vacher, Gilbert Deray
Nov 18, 2009·Transplantation Proceedings·L G Modelli de AndradeM F C Carvalho

❮ Previous
Next ❯

Citations

Apr 27, 2013·Asian Pacific Journal of Tropical Biomedicine·Saber SakrRania El-Shamy
Jul 31, 2012·International Journal of Nephrology·Jorge E ToblliM Angerosa
Nov 20, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Go KanzakiAkira Shimizu
Mar 24, 2015·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Emiko FujitaShuichi Tsuruoka
Aug 7, 2012·Molecular and Cellular Biochemistry·Monika MerkleMarkus Wörnle
Nov 21, 2012·Current Opinion in Nephrology and Hypertension·Claire M Peppiatt-Wildman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.