Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding

Chemical Communications : Chem Comm
Giuseppina De SimoneVincenzo Alterio

Abstract

N-Unsubstituted carbamates have scarcely been investigated so far as carbonic anhydrase inhibitors (CAIs). By means of kinetic and structural studies, in this paper we demonstrate that such molecules can effectively inhibit hCAs and can be used as lead compounds for the development of CAIs possessing a binding mode similar to one of the CA substrates, bicarbonate.

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Citations

Aug 23, 2019·Expert Opinion on Drug Discovery·Alessio Nocentini, Claudiu T Supuran
Jun 24, 2020·Chemical Communications : Chem Comm·Murat BozdagVincenzo Alterio
Oct 18, 2020·Metabolites·Andrea AngeliClaudiu T Supuran
Nov 5, 2019·Journal of Molecular Biology·Vincenzo AlterioGiuseppina De Simone
Feb 23, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Alessio NocentiniClaudiu T Supuran
Mar 2, 2021·Biochemical and Biophysical Research Communications·Giuseppina De SimoneVincenzo Alterio

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