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Inhibition of carboxypeptidase A by ketones and alcohols that are isosteric with peptide substrates

Biochemistry

Dec 17, 1985

D GrobelnyR E Galardy

PMID: 4092029

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Abstract

The Ki's of three peptide ketone and three peptide alcohol inhibitors of carboxypeptidase A are compared with Ki's of their respective isosteric peptide substrates, N alpha-benzoyl-L-phenylalanine, N alpha-benzoylglycyl-L-phenylalanine, and N alpha-carbobenzoxyglycylglycyl-L-phenylalani...read more

Mentioned in this Paper

Amino Acid [EPC]
4-oxopentanoic acid
Ketones
5-benzamido-2-benzyl-4-oxopentanoic acid
Metabolic Inhibition
Structure-Activity Relationship
Ketone Bodies Measurement, Quantitative
Carboxypeptidase A5
Phenylalanine
Carboxypeptidase A Activity
Paper Details
References
  • References23
  • Citations6
123

Inhibition of carboxypeptidase A by ketones and alcohols that are isosteric with peptide substrates

Biochemistry

Dec 17, 1985

D GrobelnyR E Galardy

PMID: 4092029

DOI:

Abstract

The Ki's of three peptide ketone and three peptide alcohol inhibitors of carboxypeptidase A are compared with Ki's of their respective isosteric peptide substrates, N alpha-benzoyl-L-phenylalanine, N alpha-benzoylglycyl-L-phenylalanine, and N alpha-carbobenzoxyglycylglycyl-L-phenylalani...read more

Mentioned in this Paper

Amino Acid [EPC]
4-oxopentanoic acid
Ketones
5-benzamido-2-benzyl-4-oxopentanoic acid
Metabolic Inhibition

Related Papers

Paper Details
References
  • References23
  • Citations6
123

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