PMID: 11316535Apr 24, 2001Paper

Inhibition of carotid artery neointimal formation with intravenous microbubbles

Ultrasound in Medicine & Biology
T PorterStanley J Radio

Abstract

Because therapeutic gene products such as synthetic antisense oligodeoxynucleotides (ODN) bind to albumin-coated microbubbles, we sought to determine whether IV perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles could target their delivery to the carotid artery following balloon injury. In 5 pigs, the concentration of ODN taken up within the carotid vascular wall was found to be significantly increased when the IV antisense (ODN) was administered bound to PESDA (ODN-PESDA), and while transcutaneous low-frequency (20 kHz) ultrasound was applied over the carotid artery. Based on these results, a chronic model was then developed, in which 21 pigs received either IV ODN-PESDA, ODN alone, or control, following carotid balloon injury. At 30 days following balloon injury, percent area stenosis was only 8 +/- 2% in the ODN-PESDA groups compared to 19 +/- 8% and 28 +/- 3% in the other groups (p < 0.01). IV PESDA may be a method of noninvasively targeting the delivery of therapeutic genes.

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Citations

Nov 19, 2011·Amino Acids·Sonia MelinoMuthupandian Ashokkumar
Nov 1, 2002·Biochemical and Biophysical Research Communications·Shin-ichiro MiuraKeijiro Saku
Dec 31, 2003·Ultrasound in Medicine & Biology·Jonathan P ChristiansenJonathan R Lindner
Jun 3, 2004·Nature Reviews. Drug Discovery·Jonathan R Lindner
Jul 8, 2009·Cardiovascular Research·Susan T Laing, David D McPherson
Nov 18, 2004·Cardiovascular Ultrasound·Jeane M TsutsuiRichard Thomas Porter
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
Nov 4, 2008·Journal of Pharmaceutical Sciences·Steliyan TinkovConrad Coester
Mar 1, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nicholas N KipshidzePatrick Iversen
Jan 5, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Yueh-Hsun ChuangPai-Chi Li
Mar 4, 2006·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Thomas R PorterNicholas Kipshidze
Dec 14, 2005·Ultrasound in Medicine & Biology·Tetsuya KodamaMartin J K Blomley
Sep 24, 2005·Ultrasound in Medicine & Biology·Grzegorz KorpantyRolf A Brekken
Nov 2, 2006·Expert Opinion on Drug Delivery·Sumit Paliwal, Samir Mitragotri
Jun 12, 2013·Advanced Drug Delivery Reviews·Shanmugamurthy LakshmananMichael R Hamblin
Nov 11, 2011·Journal of cardiovascular ultrasound·Kevin Wei
Jan 6, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·John C Chappell, Richard J Price

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