Abstract
Because therapeutic gene products such as synthetic antisense oligodeoxynucleotides (ODN) bind to albumin-coated microbubbles, we sought to determine whether IV perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles could target their delivery to the carotid artery following balloon injury. In 5 pigs, the concentration of ODN taken up within the carotid vascular wall was found to be significantly increased when the IV antisense (ODN) was administered bound to PESDA (ODN-PESDA), and while transcutaneous low-frequency (20 kHz) ultrasound was applied over the carotid artery. Based on these results, a chronic model was then developed, in which 21 pigs received either IV ODN-PESDA, ODN alone, or control, following carotid balloon injury. At 30 days following balloon injury, percent area stenosis was only 8 +/- 2% in the ODN-PESDA groups compared to 19 +/- 8% and 28 +/- 3% in the other groups (p < 0.01). IV PESDA may be a method of noninvasively targeting the delivery of therapeutic genes.
References
Apr 1, 1992·Circulation·M FerrellJ H Chesebro
Nov 1, 1990·The Journal of the Acoustical Society of America·C K Holland, R E Apfel
Jan 1, 1989·Journal of Cardiovascular Pharmacology·A W ClowesM A Reidy
Aug 1, 1985·Journal of the American College of Cardiology·G E AustinD F Phillips
Aug 1, 1994·Circulation·Y ShiA Zalewski
Apr 1, 1994·The Journal of Clinical Investigation·R MorishitaV J Dzau
Jun 1, 1994·Circulation·T KakutaD P Faxon
Feb 1, 1997·Cardiology Clinics·G S MintzM B Leon
Sep 1, 1997·Journal of the American College of Cardiology·F S VillanuevaW R Wagner
Dec 24, 1997·Investigative Radiology·E C UngerR H Sweitzer
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M R BennettS M Schwartz
Sep 1, 1995·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T R PorterK Kilzer
Jan 28, 1998·Circulation·Y BirnbaumR J Siegel
Sep 30, 1998·Circulation·R J PriceT C Skalak
Mar 8, 2003·Journal of Molecular and Cellular Cardiology·John M EriksonBysani Chandrasekar
Citations
Nov 19, 2011·Amino Acids·Sonia MelinoMuthupandian Ashokkumar
Nov 1, 2002·Biochemical and Biophysical Research Communications·Shin-ichiro MiuraKeijiro Saku
Dec 31, 2003·Ultrasound in Medicine & Biology·Jonathan P ChristiansenJonathan R Lindner
Feb 27, 2004·Cardiovascular Radiation Medicine·Nicholas N KipshidzePatrick Iversen
Jun 3, 2004·Nature Reviews. Drug Discovery·Jonathan R Lindner
Jul 8, 2009·Cardiovascular Research·Susan T Laing, David D McPherson
Nov 18, 2004·Cardiovascular Ultrasound·Jeane M TsutsuiRichard Thomas Porter
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
Sep 27, 2003·Radiology·Tieli LiMasahide Kuroki
Nov 4, 2008·Journal of Pharmaceutical Sciences·Steliyan TinkovConrad Coester
Mar 1, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nicholas N KipshidzePatrick Iversen
Jan 5, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Yueh-Hsun ChuangPai-Chi Li
Mar 4, 2006·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Thomas R PorterNicholas Kipshidze
Dec 14, 2005·Ultrasound in Medicine & Biology·Tetsuya KodamaMartin J K Blomley
Sep 24, 2005·Ultrasound in Medicine & Biology·Grzegorz KorpantyRolf A Brekken
Nov 2, 2006·Expert Opinion on Drug Delivery·Sumit Paliwal, Samir Mitragotri
Sep 1, 2004·Journal of the American College of Cardiology·Jeane M TsutsuiThomas R Porter
Jun 12, 2013·Advanced Drug Delivery Reviews·Shanmugamurthy LakshmananMichael R Hamblin
Nov 11, 2011·Journal of cardiovascular ultrasound·Kevin Wei
Jan 6, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·John C Chappell, Richard J Price
Mar 2, 2021·Asia-Pacific Journal of Clinical Oncology·Wei ZhangBing Hu
May 4, 2021·Drug Delivery and Translational Research·Carlos A Franco-UrquijoBruno Escalante
Jun 23, 2021·Journal of Biomedical Science·Ali JangjouAhmad Vaez
Apr 20, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·P Brent Duncan, David Needham