Inhibition of carrageenan induced inflammation in the rat knee joint by substance P antagonist.

Annals of the Rheumatic Diseases
F Y Lam, W R Ferrell

Abstract

The pathophysiology of acute joint inflammation remains unclear. Evidence is available to suggest a neurally mediated component to the inflammatory process. Acute joint inflammation in the rat knee, induced by intra-articular injection of 2% carrageenan, was reduced by 44% in animals whose knee had previously been injected with 1% capsaicin, while chronic joint denervation produced a 37% reduction. These results indicate a significant neurogenic component in this model of acute joint inflammation. Substance P may be the mediator of this response as intra-articular injection of this agent provoked an acute inflammatory response. Pretreatment of the test knee with the substance P antagonist d-Pro4,d-Trp7 9 10-SP(4-11), however, resulted in a 93% reduction of the inflammatory response to carrageenan. This unexpectedly large effect suggests that this substance P antagonist blocks both neurogenic and non-neurogenic mediators of inflammation. Sympathetic efferent fibres innervating the knee joint were not found to contribute to the neurogenic component of the inflammatory process.

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Citations

Sep 1, 1992·Medicinal Research Reviews·A Barber, R Gottschlich
Jun 1, 1994·Inflammation·J P GilliganA Y Jeng
Nov 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M BianchiF Berti
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