PMID: 8584044Sep 1, 1995Paper

Inhibition of catecholamine (noradrenaline, dopamine) release in the locus coeruleus and the hypothalamus by baroreceptor activation: identification of the involved baroreceptors

Naunyn-Schmiedeberg's Archives of Pharmacology
C SchneiderA Philippu

Abstract

We have previously shown that experimentally induced blood pressure changes modify the release rates of catecholamines in the hypothalamus and the locus coeruleus. The aim of the present investigation was to identify the peripheral baroreceptors and the centripetal pathways responsible for the changes of catecholamine release in these brain areas. In anaesthetized cats, push-pull cannulae were bilaterally inserted into the locus coeruleus and the posterior hypothalamus. The two brain areas were superfused simultaneously with artificial cerebrospinal fluid. Baroreceptor activation by phenylephrine-induced blood pressure elevation decreased the release rate of noradrenaline in the locus coeruleus and the release rates of noradrenaline and dopamine in the posterior hypothalamus. Similar effects were elicited by electrical stimulation of the central trunk of the transected vagus and aortic depressor nerves (vagus-ADN). Transection of the nerves abolished the effect of phenylephrine on the release of noradrenaline in the locus coeruleus. Nerve transections attenuated slightly the decreased release of noradrenaline elicited by phenylephrine in the posterior hypothalamus, while the reduced dopamine release rate was not influenced. The...Continue Reading

Citations

May 14, 1998·Neuroscience and Biobehavioral Reviews·R D MyersM F Lankford
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Dec 3, 1998·Neuroscience Letters·M PeterssonG Engberg
May 28, 2008·Journal of Sleep Research·Carolina LombardiPaolo Castiglioni
May 24, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·J MansouriH C Kinney
May 21, 2019·Journal of Neurochemistry·Chanawee HirunpattarasilpFelipe Freitas

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