Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

Mucosal Immunology
Senthilkumar PalaniyandiX Zhu

Abstract

The epithelial lining of the airway tract and allergen-specific IgE are considered essential controllers of inflammatory responses to allergens. The human low affinity IgE receptor, CD23 (FcɛRII), is capable of transporting IgE or IgE-allergen complexes across the polarized human airway epithelial cell (AEC) monolayer in vitro. However, it remains unknown whether the CD23-dependent IgE transfer pathway in AECs initiates and facilitates allergic inflammation in vivo, and whether inhibition of this pathway attenuates allergic inflammation. To this end, we show that in wild-type (WT) mice, epithelial CD23 transcytosed both IgE and ovalbumin (OVA)-IgE complexes across the airway epithelial barrier, whereas neither type of transcytosis was observed in CD23 knockout (KO) mice. In chimeric mice, OVA sensitization and aerosol challenge of WT/WT (bone-marrow transfer from the WT to WT) or CD23KO/WT (CD23KO to WT) chimeric mice, which express CD23 on radioresistant airway structural cells (mainly epithelial cells) resulted in airway eosinophilia, including collagen deposition and a significant increase in goblet cells, and increased airway hyperreactivity. In contrast, the absence of CD23 expression on airway structural or epithelial cel...Continue Reading

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J BeavilB J Sutton
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·A HaczkuE W Gelfand
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·M CernadasP W Finn
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·H HakonarsonM M Grunstein
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R I ZuberiF T Liu
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·A HaczkuE W Gelfand
May 3, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y Riffo-VasquezC P Page
Aug 10, 2000·The Journal of Experimental Medicine·C M Williams, S J Galli
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yingjian YouSteven L Brody
Jan 21, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kwang-Jin Kim, Asrar B Malik
Mar 15, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Linda C H YuMary H Perdue
Aug 13, 2004·American Journal of Respiratory and Critical Care Medicine·Azzeddine DakhamaErwin W Gelfand
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pooja TakharHannah J Gould
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Pierre Olivier FisetQutayba Hamid
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abdelilah Soussi GounniBouchaib Lamkhioued
Sep 21, 2005·The Journal of Experimental Medicine·Richard G HibbertJames M McDonnell
Aug 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yahong Tu, Mary H Perdue
Oct 31, 2006·Nature Immunology·Gisela WeskampCarl P Blobel
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Silvana BalzarSally E Wenzel
Jun 15, 2007·Nature Immunology·Masayuki HiranoMax D Cooper
Aug 19, 2007·Current Allergy and Asthma Reports·Daniel H ConradDavid R Gibb
Oct 24, 2007·The Journal of Allergy and Clinical Immunology·Robert P SchleimerPedro C Avila
Feb 28, 2008·Nature Reviews. Immunology·Hannah J Gould, Brian J Sutton
Jul 25, 2008·Nature·Stephen J GalliAdrian M Piliponsky
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatiana G JonesMichael F Gurish
Sep 14, 2010·Clinical and Experimental Immunology·M AcharyaW Cushley
Feb 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Senthilkumar PalaniyandiXiaoping Zhu
Jun 21, 2011·Immunological Reviews·Stephen T Holgate
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Balvinder DhaliwalBrian J Sutton
May 21, 2013·Nature Immunology·Paula Licona-LimónRichard A Flavell

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Citations

Dec 20, 2015·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Kouya Yamaki, Shin Yoshino
Feb 26, 2016·Expert Review of Vaccines·Thomas Musich, Marjorie Robert-Guroff
Mar 29, 2016·Expert Review of Clinical Pharmacology·Christopher L GraingeVanessa M McDonald
Oct 27, 2015·Immunological Reviews·Brian J Sutton, Anna M Davies
Jul 13, 2017·American Journal of Respiratory Cell and Molecular Biology·Christopher G McKnightFred D Finkelman
Dec 22, 2017·PLoS Pathogens·Simon P JochemsDaniela M Ferreira
Nov 8, 2018·Therapeutic Advances in Respiratory Disease·Corrado PelaiaGirolamo Pelaia
Dec 21, 2017·Inflammation and Regeneration·Sachiko OnoKenji Kabashima
Apr 7, 2020·Allergy·Pascal Guntern, Alexander Eggel
Apr 29, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Herbert Luke OgdenTeal S Hallstrand
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc
Feb 19, 2017·Cold Spring Harbor Perspectives in Biology·Maria Daniela Garcia-CastilloWayne I Lencer
Aug 17, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Senthilkumar PalaniyandiShaik O Rahaman
Jul 22, 2020·International Journal of Immunopathology and Pharmacology·Jakub Novosad, Irena Krčmová
Sep 24, 2019·Antibodies·Brian J SuttonSophia N Karagiannis
Dec 31, 2020·Allergy·Paul Engeroff, Monique Vogel
Mar 23, 2021·Clinical & Translational Immunology·Jordis TrischlerStefan Zielen
Mar 25, 2021·The Journal of Allergy and Clinical Immunology·Claus BachertWilliam W Busse
Oct 4, 2021·Environmental Science and Pollution Research International·Chen ZhaoHongwei Wang

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Methods Mentioned

BETA
bronchoalveolar lavage
PCR
flow cytometry
ELISA
AECs
genotyping
electrophoresis
FACS

Software Mentioned

Zen
Adobe Photoshop

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