Inhibition of cell adhesion by xARVCF indicates a regulatory function at the plasma membrane.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Wolfgang E ReintschFrançois Fagotto

Abstract

The cytoplasmic tail of cadherins is thought to regulate the strength and dynamics of cell-cell adhesion. Part of its regulatory activity has been attributed to a membrane-proximal region, the juxtamembrane domain (JMD), and its interaction with members of the p120 catenin subfamily. We show that titration of xARVCF, a member of this family, to the plasma membrane disrupts adhesion in the early embryo. Adhesion can be restored by coexpression of constitutively active Rac, suggesting that intracellular signaling is the primary cause in the loss of adhesion phenotype. Our observations suggest that the recruitment of p120 type catenins to the plasma membrane by the cadherin cytoplasmic tail may create protein complexes, which actively modulate the adhesion "status" of embryonic cells.

References

Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Dec 1, 1985·Molecular and Cellular Biology·G I EvanJ M Bishop
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L RimmJ S Morrow
Apr 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H A Müller, P Hausen
Dec 1, 1995·Cell Adhesion and Communication·F Broders, J P Thiery
Oct 1, 1996·The Journal of Cell Biology·W M BrieherB M Gumbiner
May 4, 1999·The Journal of Cell Biology·S AonoM Takeichi
Jun 18, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T KurthP Hausen
Feb 9, 2000·The Journal of Cell Biology·B M Gumbiner
Jul 19, 2000·The Journal of Biological Chemistry·A F PaulsonP D McCrea
Aug 10, 2000·The Journal of Cell Biology·N K NorenB Kreft
Sep 12, 2000·Nature Cell Biology·P Z AnastasiadisA B Reynolds
Oct 19, 2000·The Journal of Cell Biology·S KanajiK Mihara
Sep 7, 2001·Current Opinion in Cell Biology·P Z Anastasiadis, A B Reynolds
Jan 16, 2002·The Journal of Cell Biology·Carien M Niessen, Barry M Gumbiner
Sep 17, 2002·Current Opinion in Cell Biology·Vania M M Braga
Nov 5, 2002·Biochemical and Biophysical Research Communications·Mark D HensCaron M Woolcock
Nov 13, 2002·The Journal of Cell Biology·Renee C IretonAlbert B Reynolds
Feb 26, 2003·Cell·Mirna Perez-MorenoElaine Fuchs
Mar 21, 2003·Developmental Biology·Duke DuguayMalcolm S Steinberg
Aug 19, 2003·The Journal of Biological Chemistry·Kevin C MirandaJennifer L Stow
Nov 12, 2003·The Journal of Cell Biology·Michael A DavisAlbert B Reynolds
Dec 3, 2003·Nature Cell Biology·Agnieszka KobielakElaine Fuchs
Apr 7, 2004·The Journal of Cell Biology·Xiang FangPierre D McCrea
Apr 12, 2005·European Journal of Cell Biology·Mechthild Hatzfeld
Jul 19, 2005·Nature Reviews. Molecular Cell Biology·Barry M Gumbiner
Aug 17, 2005·The Journal of Cell Biology·Wolfgang E ReintschFrançois Fagotto
Dec 6, 2005·Cell·Soichiro YamadaW James Nelson
Feb 25, 2006·The Journal of Biological Chemistry·Jennifer L SalleeKeith Burridge
Aug 15, 2006·Current Opinion in Cell Biology·René-Marc MègeMireille Lambert
Sep 1, 2006·Biochimica Et Biophysica Acta·Pierre D McCrea, Jae-Il Park

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Citations

May 6, 2015·Prostate Cancer and Prostatic Diseases·K L PenneyJ L Stanford
Aug 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniel W LinJanet L Stanford
Aug 3, 2012·Journal of Proteome Research·Renee WangFrançois Fagotto

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