Inhibition of cell cycle progression on HepG2 cells by hypsiziprenol A9, isolated from Hypsizigus marmoreus

Cancer Letters
Jong-Sun ChangKap-Rang Lee

Abstract

Antiproliferative activities of fractions of Hypsizigus marmoreus were examined using HepG2 cells in vitro. The methanol extract of H. marmoreus markedly induced antiproliferative activity, and an active compound from this mushroom was identified as hypsiziprenol A9. Hypsiziprenol A9 inhibited cell proliferation in a time- and concentration-dependent manner by up to 80% on HepG2 cells by inducing arrest of the G1 phase. Further investigation revealed that hypsiziprenol A9 decreased expression of phosphorylated retinoblastoma protein (ppRb), cyclin D1, and cyclin E in a dose-dependent manner. These results suggest that hypsiziprenol A9 can inhibit the growth of HepG2 cells through inducing G1 phase cell cycle arrest due to the inhibition of pRb phosphorylation.

References

Jul 1, 1992·Chemical & Pharmaceutical Bulletin·T IkekawaT Matsuzawa
Jan 1, 1990·Acta Oncologica·A B Miller
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Mar 26, 1993·Science·M Ohtsubo, J M Roberts
Jan 1, 1996·Bioscience, Biotechnology, and Biochemistry·T MizunoY Mayuzumi
Dec 6, 1996·Science·C J Sherr
Nov 14, 1997·Science·W K Hong, M B Sporn
Jan 13, 1998·Biochimica Et Biophysica Acta·R Bernards
Aug 25, 1999·Proceedings of the Society for Experimental Biology and Medicine·A T BorchersM E Gershwin
Feb 24, 2001·Bioscience, Biotechnology, and Biochemistry·E W LeeH Kawagish
Mar 21, 2001·Human Molecular Genetics·J R Nevins
May 18, 2001·Nature·G I Evan, K H Vousden
May 26, 2001·The Journal of Biological Chemistry·A L AllanJ LaMarre
Jan 16, 2002·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·V Mohacek-GrosevG J Puppels
Jun 18, 2002·Cancer Letters·Chau Jong WangTsui Hwa Tseng
Sep 6, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·A AlisiL Conti Devirgiliis
Feb 24, 2004·Journal of Medicinal Food·Noriko KodamaHiroaki Nanba
Apr 4, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ye Jian, Wang Jingze
Jun 15, 2013·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Hsu-Chung LiuChuan-Mu Chen

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Citations

Jul 25, 2009·Journal of Medicinal Food·Jong Sun ChangKap Rang Lee
Aug 20, 2014·BMC Complementary and Alternative Medicine·Dinesh Singh MoirangthemNarayan Chandra Talukdar
May 23, 2015·Journal of Nutritional Science and Vitaminology·Takujiro IuchiTakuya Awata
Mar 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lj HarhajiS Stosić-Grujicić
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Fu-Qiang SongGe Song

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