Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue

Journal of Enzyme Inhibition
Jean-Bernard BehrN S Ryder

Abstract

The synthesis and biological evaluation of a new UDP-GlcNAc competitor (I), designed to mimic the transition state of the sugar donor in the enzymatic reaction catalysed by chitin synthetase, is described. Compound (I) was found to competitively inhibit chitin synthetase from Saccharomyces cerevisiae with respect to UDP-GlcNAc, but displayed minimal antifungal activity.

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Citations

Jun 5, 2004·Carbohydrate Research·Robert ChangNathaniel S Finney
Sep 26, 2001·Yeast
Jun 23, 2005·Journal of Enzyme Inhibition and Medicinal Chemistry·Mounira Djebaili, Jean-Bernard Behr
Apr 22, 2021·Organic & Biomolecular Chemistry·Irene Conforti, Alberto Marra
Jul 8, 2018·Gene·Larissa Catharina, Nicolas Carels
Nov 24, 2004·Bioorganic & Medicinal Chemistry·Adam R Yeager, Nathaniel S Finney

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