PMID: 69783Jul 23, 1977Paper

Inhibition of cholecystokinin-pancreozymin release by somatostatin

Lancet
W SchlegelE F Pfeiffer

Abstract

To determine the effect of somatostatin on cholecystokinin-pancreozymin (C.C.K.) release, serum-C.C.K. concentrations were measured in normal volunteers after intraduodenal olive oil, with and without a simultaneous intravenous infusion of somatostatin. After instillation of the olive oil there was a rapid rise in serum-C.C.K. (integrated response 19 682+/-5632 pg min ml-1). This rise was completely abolished by somatostatin (integrated response -373+/-330 pg min ml-1, P less than 0-005) and rebound hyper-secretion was seen after the infusion had been stopped. These findings indicate that somatostatin may be involved in regulating C.C.K. release after meals, and suggest a possible explanation for the profound steatorrhoea seen in a patient with a somatostatin-producing tumour.

Citations

Jan 1, 1981·Diabetologia·R H Unger
Mar 1, 1989·Digestive Diseases and Sciences·P N MatonR T Jensen
Dec 5, 1995·Journal of the Autonomic Nervous System·M MasudaA Funakoshi
Jun 1, 1982·Regulatory Peptides·J MorissetT E Solomon
Aug 9, 1979·The New England Journal of Medicine·G J KrejsR H Unger
Oct 23, 1980·The New England Journal of Medicine·K H UsadelK K Uberla
Jul 1, 1991·Gut·G J PostonP J Guillou
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·W Y Chey, T Chang
Jul 18, 2015·Expert Opinion on Drug Safety·Ludovica F S GrassoAnnamaria Colao
May 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J R HuertasF J Mataix
Feb 1, 1991·Scandinavian Journal of Gastroenterology·P LayerC Beglinger
Aug 1, 1979·Metabolism: Clinical and Experimental·D J GoldbergR S Sherwin
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·K KutzJ Rosenthaler
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·S L LightmanM J Dunne
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·S A Raptis, S D Ladas
Jan 1, 1978·Scandinavian Journal of Gastroenterology·L KayassehJ Girard
Jan 1, 1978·Scandinavian Journal of Gastroenterology·C JohanssonR Luft
Sep 1, 1993·Seminars in Surgical Oncology·M J Demeure
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·S Reichlin
Jan 1, 1979·Annals of Clinical Biochemistry·E PenmanL H Rees
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Grossman
Jun 1, 1990·Current Problems in Surgery·E MozellT M O'Dorisio
Nov 1, 1978·Metabolism: Clinical and Experimental·R H Unger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.