Inhibition of chronic ulcerative colitis-associated adenocarcinoma development in mice by VSL#3

Inflammatory Bowel Diseases
E TaleroV Motilva

Abstract

Colorectal cancer is the most severe complication in inflammatory bowel disease. This study aimed to investigate the effects of the probiotic VSL#3 when administered as either preventive or concurrent treatment in the progression from chronic colitis to colon cancer. Mice were exposed to 5, 10, and 15 cycles of dextran sulfate sodium (DSS); each cycle consisted of 0.7% DSS for 1 week followed by distilled water for 10 days. VSL#3 was administered either from 2 weeks before the colitis induction or from the first day of the colitis until being killed. After each period, macroscopic and histological studies, as well as analysis of inflammatory and tumor biomarkers, were performed. Prophylactic or concurrent VSL#3 administration attenuated the disease activity index score and colon inflammation after 5, 10, and 15 cycles of DSS, as well as reduced the histological alterations and the incidence of colonic dysplastic lesions at the 3 periods studied. None of the animals receiving VSL#3 as a concurrent treatment developed carcinoma, which is in contrast to 5% and 20% of the mice following preventive VSL#3 administration, developing carcinoma at the 10th and the 15th cycles of DSS, respectively. In addition, the probiotic reduced the ...Continue Reading

References

Aug 31, 2002·Journal of Gastroenterology and Hepatology·Isao OkayasuToshifumi Ohkusa
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia Di GiacintoMonica Boirivant
Mar 21, 2008·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·I SooR N Fedorak
Sep 11, 2008·Inflammation & Allergy Drug Targets·Maximilian J Waldner, Markus F Neurath
Feb 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rudolf MennigenMatthias Bruewer
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Piero VavassoriStefano Fiorucci
Jun 22, 2010·Inflammatory Bowel Diseases·Joshua M UronisChristian Jobin
Jul 12, 2011·Cancer Letters·Yuanmin ZhuHoward A Young
Sep 10, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Caroline B AppleyardClaudio De Simone
May 10, 2012·FEMS Microbiology Letters·Ravinder NagpalHariom Yadav
Aug 10, 2012·World Journal of Gastroenterology : WJG·Jessica K Dyson, Matthew D Rutter
Aug 15, 2012·Current Allergy and Asthma Reports·Neil ShahErik-Oliver Glocker
Aug 16, 2012·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Dan A DixonPaola Patrignani
Nov 22, 2013·World Journal of Gastroenterology : WJG·Jian Cheng, Xiao-Ming Fan
Jan 22, 2014·The Journal of Nutritional Biochemistry·Toru TakashimaKazuma Fujimoto
Feb 25, 2014·Gastroenterology·Aleksandar D KosticDirk Gevers
May 6, 2014·American Journal of Surgery·Kristel C Lobo PrabhuSam M Wiseman
Jun 20, 2014·World Journal of Gastroenterology : WJG·Marco ScarpaImerio Angriman

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Citations

Jun 2, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Solat EslamiMohammad Reza Khoramizadeh
Dec 30, 2015·Journal of Gastroenterology and Hepatology·Eun-Ju DoSeung-Jae Myung
Oct 30, 2016·Current Opinion in Oncology·Stephanie S Y SoHani El-Nezami
Jul 12, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Raymond A IsidroCaroline B Appleyard
Mar 27, 2019·Journal of Cellular Physiology·Majid EslamiAfshin Namdar
Apr 6, 2019·Current Microbiology·Agata GórskaJulita Kulbacka
Jul 11, 2019·International Journal of Cancer. Journal International Du Cancer·Tianyu LiuHailong Cao
May 19, 2019·Journal of Applied Microbiology·Yan ZhouFangyan Wang
Feb 28, 2020·Chinese Medical Journal·Peng-Guang Yan, Jing-Nan Li
Sep 10, 2020·Applied Microbiology and Biotechnology·Bruna Cristina Dos Santos CruzMaria do Carmo Gouveia Peluzio
Oct 13, 2018·World Journal of Gastroenterology : WJG·Chun-Sai-Er WangJing-Nan Li
Jun 25, 2020·Vaccines·Georgios Aindelis, Katerina Chlichlia
Jun 12, 2020·Frontiers in Oncology·Concetta PanebiancoValerio Pazienza
May 3, 2020·International Journal of Molecular Sciences·Takehiro HiranoHiroshi Nakase
Sep 29, 2020·Human Fertility : Journal of the British Fertility Society·Bijan HelliHossein Khadem Haghighian
Dec 6, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Xiali QinHailong Cao
Dec 31, 2020·Cancers·Katarzyna ŚliżewskaWeronika Śliżewska

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