Inhibition of class I HDACs attenuates renal interstitial fibrosis in a murine model

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Min YangZhonghua Klaus Chen

Abstract

Renal interstitial fibrosis is the most common of all the forms of chronic kidney disease (CKD). Research has shown that histone deacetylases (HDACs) participate in the process leading to renal fibrosis. However, the effects of class I HDAC inhibitors on the mechanisms of onset and progression of renal interstitial fibrosis are still unclear. Here, we present the effects and mechanisms of action of FK228 (a selective inhibitor of class I HDACs) in the murine model of unilateral ureteral obstruction (UUO) and in vitro models. We investigated the antifibrotic role of FK228 in a murine model of UUO. We used two key effector cell populations, rat renal interstitial fibroblasts and renal tubular epithelial cells exposed to recombinant transforming growth factor-beta 1 (TGF-β1), to explore the mechanistic pathways among in vitro models. The results indicated that FK228 significantly suppressed the production of extracellular matrix (ECM) in both in vivo and in vitro models. FK228 inhibited renal fibroblast activation and proliferation and increased the acetylation of histone H3. We found that FK228 also inhibited the small mothers against decapentaplegic (Smad) and non-Smad signaling pathways. So FK228 could significantly suppress re...Continue Reading

Citations

Apr 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yunhe ZhangShougang Zhuang
Oct 8, 2020·Cell Death and Differentiation·Fang ChenWangsen Cao
Feb 7, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jinkun Xia, Wangsen Cao
Jan 6, 2021·Clinical and Experimental Nephrology·Hongbing Liu
Aug 27, 2021·Cellular Signalling·Alexis Paulina Jiménez-UribeJosé Pedraza-Chaverri
Sep 10, 2020·Kidney Diseases·Ling NieJinghong Zhao

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