Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses

Nature
Javier F MedinaMichael D Mauk

Abstract

A fundamental tenet of cerebellar learning theories asserts that climbing fibre afferents from the inferior olive provide a teaching signal that promotes the gradual adaptation of movements. Data from several forms of motor learning provide support for this tenet. In pavlovian eyelid conditioning, for example, where a tone is repeatedly paired with a reinforcing unconditioned stimulus like periorbital stimulation, the unconditioned stimulus promotes acquisition of conditioned eyelid responses by activating climbing fibres. Climbing fibre activity elicited by an unconditioned stimulus is inhibited during the expression of conditioned responses-consistent with the inhibitory projection from the cerebellum to inferior olive. Here, we show that inhibition of climbing fibres serves as a teaching signal for extinction, where learning not to respond is signalled by presenting a tone without the unconditioned stimulus. We used reversible infusion of synaptic receptor antagonists to show that blocking inhibitory input to the climbing fibres prevents extinction of the conditioned response, whereas blocking excitatory input induces extinction. These results, combined with analysis of climbing fibre activity in a computer simulation of the...Continue Reading

References

Jan 1, 1992·Annual Review of Neuroscience·W T ThachJ G Keating
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M D MaukR F Thompson
Jun 1, 1969·The Journal of Physiology·D Marr
Jun 1, 1993·Current Opinion in Neurobiology·D J Linden, J A Connor
May 24, 1996·Science·J L RaymondM D Mauk
Jun 1, 1996·Experimental Brain Research·G Hesslow, M Ivarsson
Sep 15, 1998·Trends in Neurosciences·J Voogd, M Glickstein
Sep 15, 1998·Trends in Neurosciences·C I De ZeeuwT J Ruigrok
Oct 1, 1998·Neurobiology of Learning and Memory·R F ThompsonP G Shinkman
Apr 9, 1999·Nature Neuroscience·J R Hollerman, W Schultz
Jun 9, 2000·Annual Review of Neuroscience·W Schultz, A Dickinson
Dec 29, 2000·Nature Neuroscience·J F Medina, M D Mauk

❮ Previous
Next ❯

Citations

Oct 31, 2008·The Cerebellum·Paul Dean, John Porrill
Aug 22, 2006·Biological Psychiatry·Gregory J Quirk
Apr 12, 2003·Trends in Neurosciences·Tatsuya OhyamaMichael D Mauk
Oct 28, 2004·Behavioral Neuroscience·Daniel A Nicholson, John H Freeman
Apr 15, 2003·Nature Neuroscience·Daniel A Nicholson, John H Freeman
Oct 31, 2002·The European Journal of Neuroscience·Constanze HofstötterPaul F M J Verschure
Mar 11, 2006·The Cerebellum·Fredrik Bengtsson, Germund Hesslow
Aug 23, 2007·Neuroreport·Fredrik BengtssonGermund Hesslow
Jan 16, 2009·Learning & Memory·Brian E KalmbachMichael D Mauk
Oct 5, 2011·Learning & Memory·John H Freeman, Adam B Steinmetz
Sep 24, 2011·Learning & Memory·Adam B Steinmetz, John H Freeman
Mar 14, 2007·Learning & Memory·Matthew M CampolattaroJohn H Freeman
Oct 15, 2003·Learning & Memory·John H Freeman, Adam S Muckler
Oct 7, 2004·Learning & Memory·Marlene R CohenJennifer L Raymond
Feb 13, 2003·Annals of the New York Academy of Sciences·Alan R GibsonMilton Pong
Feb 13, 2003·Annals of the New York Academy of Sciences·Tatsuya OhyamaMichael D Mauk
Feb 5, 2010·Journal of Neurophysiology·Brian E KalmbachMichael D Mauk
May 21, 2010·Journal of Neurophysiology·Brian E KalmbachMichael D Mauk
Aug 3, 2007·Journal of Neurophysiology·Daniel Z WetmoreMark J Schnitzer
Sep 24, 2011·Journal of Neurophysiology·Brian E Kalmbach, Michael D Mauk
Jun 12, 2004·Behavioral and Cognitive Neuroscience Reviews·John H Freeman, Daniel A Nicholson
Apr 12, 2011·Reviews in the Neurosciences·Ingie HongSukwoo Choi
Jul 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hunter E HalversonJohn H Freeman
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeong-Yoon Lee, Nicolas Schweighofer
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tatsuya OhyamaMichael D Mauk
May 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew J CarrelVlastislav Bracha
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joy C Kreider, Michael D Mauk
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul J MathewsThomas S Otis
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian E KalmbachMichael D Mauk
Aug 22, 2013·The Cerebellum·W T Thach
Jan 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeongyeon KimSukwoo Choi
Dec 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Varda Lev-RamRoger Y Tsien
Apr 24, 2014·ELife·Rhea R KimpoJennifer L Raymond
Apr 14, 2011·The Journal of Physiology·Rodolfo R Llinás
Apr 20, 2011·The Journal of Physiology·Paul Dean, John Porrill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Dan-Anders JirenhedGermund Hesslow
Journal of Neurophysiology
Daniel A Nicholson, John H Freeman
The European Journal of Neuroscience
Fredrik BengtssonGermund Hesslow
© 2022 Meta ULC. All rights reserved