Inhibition of complement activation by a secreted Staphylococcus aureus protein

The Journal of Infectious Diseases
Lawrence Y L LeeEric L Brown

Abstract

Staphylococcus aureus can cause a variety of acute and chronic diseases. The ability of S. aureus to cause persistent infections has been linked to its ability to evade or inactivate host immune responses. We have identified a secreted 19-kDa protein produced by S. aureus that binds to the complement protein C3. N-terminal sequencing of this protein identified it as the extracellular fibrinogen-binding protein (Efb). In this study, we demonstrate that Efb can bind to the alpha -chain of C3 and inhibit both the classical and alternative pathways of complement activation. In addition, we show that Efb can inhibit complement-mediated opsonophagocytosis in a dose-dependent manner and that Efb inhibits complement activity by blocking deposition of C3 or by preventing further complement activation beyond C3b. These data suggest that Efb is a virulence factor involved in facilitating persistent S. aureus infections by interfering with complement activity in vivo.

Citations

Nov 4, 2011·Seminars in Immunopathology·James E Cassat, Eric P Skaar
Mar 14, 2007·Nature Immunology·Michal HammelBrian V Geisbrecht
Dec 3, 2005·Nature Reviews. Microbiology·Timothy J Foster
Jan 17, 2008·Nature Reviews. Microbiology·John D LambrisBrian V Geisbrecht
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hui ChenJohn D Lambris
Jan 21, 2011·The Journal of Biological Chemistry·Ya-Ping KoMagnus Höök
Sep 26, 2007·The Journal of Experimental Medicine·Ilse JongeriusSuzan H M Rooijakkers
Jun 12, 2008·The Journal of Infectious Diseases·Pamela S HairKenji M Cunnion
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Michal HammelBrian V Geisbrecht
Jan 16, 2008·Infection and Immunity·Christy L VenturaCraig E Rubens
Jul 10, 2013·Annual Review of Microbiology·András N SpaanJos A G van Strijp
Sep 5, 2012·Biological Chemistry·Michal Potempa, Jan Potempa
Jul 25, 2008·Future Microbiology·Dirk Kraus, Andreas Peschel
Sep 18, 2007·Immunologic Research·Pieter-Jan Haas, Jos van Strijp
May 30, 2009·Molecular Immunology·Anna M BlomKristian Riesbeck
May 21, 2013·International Journal of Medical Microbiology : IJMM·Carsten FehrmannChristine Heilmann
Apr 23, 2015·Journal of Periodontal Research·L J PalmerC H Nielsen
Jul 10, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stephanie N ShishidoSherry D Fleming
Sep 5, 2007·Molecular Immunology·Peter F ZipfelChristine Skerka
Aug 8, 2007·Trends in Immunology·Triantafyllos ChavakisMathias Herrmann
Aug 9, 2008·Protein Science : a Publication of the Protein Society·Nurit HaspelJohn D Lambris
Aug 3, 2006·Cellular Microbiology·Suzan H M RooijakkersWillem J B van Wamel
Sep 11, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Torgny SchenningsJan-Ingmar Flock
Aug 3, 2006·The Journal of Infection·Javier Oviedo-BoysoVíctor M Baizabal-Aguirre
Aug 1, 2006·Molecular Immunology·Suzan H M Rooijakkers, Jos A G van Strijp
Oct 26, 2005·Trends in Microbiology·Suzan H M RooijakkersJos A G van Strijp
May 26, 2015·Veterinary Immunology and Immunopathology·Renata GrzywaMarcin Sieńczyk
Jun 16, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Jun 11, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Miguel CavadasRicardo Franco
Nov 17, 2007·Cell Host & Microbe·Victor J TorresEric P Skaar
Mar 15, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Oguz KarabayCihangir Uyan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.