Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition

Annual Review of Pharmacology and Toxicology
J M Fukuto, G Chaudhuri

Abstract

Nitric oxide (NO) is a molecule that has been shown to be involved in a diverse array of physiological events. A variety of disease states and disorders are, in fact, due to either an over- or an underproduction of NO. As a result of the ubiquity and diversity of NO-mediated phenomenon, pharmacological manipulation is difficult. NO biosynthesis is the result of an oxidation of a terminal nitrogen on the amino acid arginine by a class of enzymes generally referred to as the nitric oxide synthases (NOSs). Since the various isoforms of NOS are distributed in cells and tissues according to their function, there is the possibility that manipulation of NO levels can be accomplished by designing specific pharmacological agents targeted at a single NOS isoform. Thus, this review discusses general inhibition of the NOSs by a variety of agents and then focuses on the possibility of developing agents for specific isoform inhibition.

Citations

Oct 6, 1997·Neurochemistry International·V Chaparro-HuertaA Feria-Velasco
Mar 29, 2001·Progress in Neurobiology·H Wiesinger
Aug 26, 1998·Journal of the American College of Cardiology·K AkiyamaR J Bing
Aug 12, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R VozzoJ E Morley
Sep 16, 1998·Current Opinion in Chemical Biology·B R Babu, O W Griffith
Apr 1, 1997·British Journal of Pharmacology·S N HeymanD Rachmilewitz
May 12, 2000·British Journal of Pharmacology·F SquadritoA P Caputi
Apr 1, 2003·Animal Health Research Reviews·Robert P Hunter
May 20, 1999·Annual Review of Pharmacology and Toxicology·A J HobbsS Moncada
Oct 8, 1999·The Journal of Clinical Investigation·G CalapaiA P Caputi
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Toshio HayashiGautam Chaudhuri
May 4, 1999·European Journal of Pharmacology·A BeirithJ B Calixto
Mar 1, 1997·Equine Veterinary Journal·S P FreanP Lees
Oct 15, 1998·Toxicology·J Venkateswara RaoY Venkateswarlu
Apr 29, 1999·European Journal of Cell Biology·M Wilken, B Huchzermeyer
Feb 23, 1996·Biochemical Pharmacology·G J Southan, C Szabó
Apr 27, 2002·American Journal of Surgery·Peter B SoetersNicolaas E P Deutz
Jun 12, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M M HallemeeschN E P Deutz
Mar 20, 1999·Neurobiology of Learning and Memory·B Samama, N Boehm
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M GiddayT S Park
Jan 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·M A BroedersM G Egbrink
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·M A BroedersM G oude Egbrink
Nov 16, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Isabel DevesaMaria José Alcaraz
Mar 1, 2001·Stress : the International Journal on the Biology of Stress·C Rivier
Mar 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Yeonsoo JoeHun Taeg Chung
Oct 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Ana María VicenteMaría José Alcaraz

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