Abstract
The effects of noradrenaline uptake inhibitors on contractions evoked by electric field stimulation, noradrenaline, clonidine. 5-hydroxytryptamine, ATP, high K+, and BaCl2 in the epididymal half of rat isolated vas deferens were examined. Protriptyline, amitriptyline and xylamine concentration-dependently inhibited monophasic contractions induced by low frequency electrical stimulation (0.3 Hz, 1 ms duration, 60 V). Protriptyline and xylamine inhibited in a noncompetitive manner the contractile response induced by noradrenaline (3 x 10(-8)-3 x 10(-5) M) and the inhibitory effect of protriptyline was reversible, while xylamine produced long-lasting inhibition. All three noradrenaline uptake blockers inhibited the clonidine (3 x 10(-6) M) or 5-hydroxytryptamine (10(-5) M)-induced contraction. Protriptyline and amitriptyline at concentrations of 3 x 10(-6)-3 x 10(-5) M reversibly inhibited the ATP (10(-4) M)-induced monophasic contraction. In contrast, xylamine ((1-3) x 10(-5) M) had no effect. Protriptyline and amitriptyline but not xylamine concentration-dependently reduced the high K+ (6 x 10(-2) M)-induced sustained contraction with respective IC50 values of 1.81 x 10(-6) M and 8.6 x 10(-7) M. Protriptyline and amitriptyline a...Continue Reading
References
Feb 28, 1991·The New England Journal of Medicine·J M Astrachan
Jan 22, 1985·European Journal of Pharmacology·G Isenberg, J Tamargo
May 4, 1987·Life Sciences·M RehaviS Cohen
Sep 30, 1985·Life Sciences·R W RansomA K Cho
Nov 1, 1968·European Journal of Pharmacology·Y Kasuya, K Goto
Oct 1, 1967·The Journal of Pharmacy and Pharmacology·P Hrdina, S Garattini
Sep 1, 1969·British Journal of Pharmacology·J R BassettM Story
May 22, 1970·Biochemical and Biophysical Research Communications·C Van Breemen, E McNaughton
Dec 1, 1981·British Journal of Pharmacology·P DemichelJ Roquebert
Nov 1, 1981·The Journal of Pharmacy and Pharmacology·S A Doggrell, L Vincent
Aug 17, 1984·European Journal of Pharmacology·E Richelson, A Nelson
Feb 1, 1984·Journal of Neurochemistry·R W RansomA K Cho
Apr 1, 1980·Urology·M E BrooksZ Braf
Jul 1, 1995·British Journal of Pharmacology·Y Huang
Feb 1, 1996·British Journal of Pharmacology·Y Huang
Jan 1, 1965·The Journal of Pharmacy and Pharmacology·L L IVERSEN
Citations
Mar 29, 2000·Urology·P MedinaS Lluch
Aug 30, 2008·The Journal of Physiology·Ye Chun RuanWen Liang Zhou
Jul 22, 2014·TheScientificWorldJournal·Vijayapandi PandyZahurin Mohamed
Jul 27, 1999·British Journal of Clinical Pharmacology·J M VilaS Lluch