Inhibition of COX in ocular tissues: an in vitro model to identify selective COX-2 inhibitors

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
C García-CabanesA Orts

Abstract

The aim of this work was to study the regulation of LPS-stimulated PGE 2 synthesis by traditional NSAIDs (piroxicam and diclofenac) and a selective COX-2 inhibitor (NS-398), in cultured bovine corneal endothelial cells and retinal pigmentary epithelial cells. The IC50 values of piroxicam and diclofenac were compared with IC50 values of NS-398, diclofenac, in both types of cells, showed higher potency than piroxicam. Diclofenac seemed to be a COX-2 inhibitor because its IC50 values were similar to the IC50 values of NS-398. We suggest that this in vitro cell assay system could be useful for identifying compounds that selectively inhibit COX-2 in ocular tissues.

References

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Dec 1, 1998·Ophthalmic Research·C García-CabanesA Orts

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Citations

Mar 1, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·L David WaterburyDavid A Hollander
Oct 3, 2006·American Journal of Ophthalmology·João Pessoa Souza FilhoMiguel N Burnier

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