Inhibition of cultivable bacteria by chlorhexidine treatment of dentin lesions treated with the ART technique

Caries Research
Nazan Kocatas ErsinCemal Eronat

Abstract

The aim of this study was to examine the changes in the cultivable microflora of carious dentin before and after atraumatic restorative treatment (ART) and investigate the inhibitory effect of chlorhexidine-gluconate-based cavity disinfectant in the microflora. Using a split mouth design, 35 primary molar pairs with class II carious lesions in 35 patients (mean age 7.31+/-0.47 years) were selected. The total viable counts (TVC), Streptococcus mutans and lactobacilli were first measured in the center of the infected demineralized lesion and then from the hard dentine after caries removal by the ART technique. Chlorhexidine-gluconate (2%)-based cavity disinfectant was applied to one of the molar pairs and the other molar received no disinfectant treatment. Thereafter, all of the teeth were restored with glass ionomer cement (GIC). Cavities were reassessed after 6 months and again dentine samples were microbiologically investigated. Removal of carious dentine by ART significantly reduced TVC, S. mutans and lactobacilli. After 6 months, application of chlorhexidine exhibited a greater significant reduction in TVC (p=0.013), and a significant reduction in S. mutans compared to the nondisinfected group (p<0.001). A significant reduct...Continue Reading

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Citations

Mar 1, 2012·Journal of Conservative Dentistry : JCD·Fátima Maria Cavalcante BorgesLidiany Karla Azevedo Rodrigues
Jan 19, 2012·Acta Odontologica Scandinavica·Ferhan EgilmezLippo V J Lassila
Dec 30, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Vinicius Di HipólitoPaulo Henrique Perlatti D'Alpino
Aug 21, 2014·Annals of Clinical Microbiology and Antimicrobials·Matilde Ruiz-LinaresPilar Baca
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Oct 3, 2007·The Journal of the American Dental Association·Esti DavidovichNurit Beyth
Feb 7, 2019·Journal of Oral Science·Maribasappa KarchedHien Ngo
May 14, 2021·Clinical Oral Investigations·Meltem Tekbas Atay, Fatma Koray
May 29, 2021·Scientific Reports·Mahmoud K Al-OmiriEdward Lynch

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