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Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

Journal of Neuroinflammation

Jan 6, 2018

Anna WilkaniecGrzegorz A Czapski

Abstract

Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis. The deregulation of Cdk5 activity was observed in post morte...read more

Mentioned in this Paper

Hippocampus (Brain)
Protein Kinase Inhibitors
Tumor Necrosis Factor-alpha
Microglia
Inflammation
Metabolic Inhibition
Injections, Intraperitoneal
Interleukin-1
Interleukin-6
Alzheimer's Disease Pathway Kegg
2
24

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Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

Journal of Neuroinflammation

Jan 6, 2018

Anna WilkaniecGrzegorz A Czapski

PMID: 29301548

DOI: 10.1186/s12974-017-1027-y

Abstract

Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis. The deregulation of Cdk5 activity was observed in post morte...read more

Mentioned in this Paper

Hippocampus (Brain)
Protein Kinase Inhibitors
Tumor Necrosis Factor-alpha
Microglia
Inflammation
Metabolic Inhibition
Injections, Intraperitoneal
Interleukin-1
Interleukin-6
Alzheimer's Disease Pathway Kegg
2
24

Similar Papers Found In These Feeds

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