Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas

European Journal of Pharmacology
Surya P AyalasomayajulaUday B Kompella

Abstract

Up-regulation of cyclooxygenase-2 occurs in retinal cells during the early onset of diabetic retinopathy. Under these conditions, prostaglandin production is elevated, which in turn leads to an increased expression of vascular endothelial growth factor (VEGF)--a growth factor implicated in vascular leakage and neovascularization. In this ex vivo study, we tested whether cyclooxygenase-1 or cyclooxygenase-2 is responsible for diabetes-induced secretion of prostaglandin E2 from isolated rat retinas. Celecoxib, a selective cyclooxygenase-2 inhibitor, significantly inhibited prostaglandin E2 secretion, whereas SC560 [5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole], a selective cyclooxygenase-1 inhibitor, had no inhibitory effect. These results suggests that the enzymatic activity of cyclooxygenase-2, but not cyclooxygenase-1, results in prostaglandin E2 secretion under diabetic conditions.

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Citations

Nov 7, 2008·Pharmaceutical Research·Narayan P S CheruvuUday B Kompella
Oct 1, 2013·Biochemical Pharmacology·Gabriella LupoClaudio Bucolo
Mar 22, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zaher A Radi, James A Render
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May 6, 2015·International Journal of Molecular Medicine·Jianyan HuQiang Wu
Sep 1, 2015·Journal of the American Society of Nephrology : JASN·Rania NasrallahRichard L Hébert
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Feb 24, 2009·Toxicologic Pathology·Zaher A Radi
Sep 10, 2020·Drug Delivery and Translational Research·Sherif A GaballaHamdy Abdelkader

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