Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa

FEBS Letters
J J HongG T Oh

Abstract

Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 microM), a major component of A. rugosa, inhibits the tumor necrotic factor-alpha (TNF-alpha)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 microM) reduced TNF-alpha-induced activation of nuclear factor-kappaB in HUVECs.

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Citations

May 29, 2012·Journal of Agricultural and Food Chemistry·Pham Anh TuanSang Un Park
Jun 6, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Sylwia Zielińska, Adam Matkowski
Jun 23, 2015·Biomedical Chromatography : BMC·Kebede Taye DestaSung Chul Shin
Dec 17, 2014·BMC Complementary and Alternative Medicine·Hanaa YamaniEdwin Pang
Jan 2, 2013·Journal of Ethnopharmacology·Oswaldo Hernández-AbreuSamuel Estrada-Soto
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jorge Alberto García-DíazSamuel Estrada-Soto
Jun 22, 2017·International Journal of Biological Macromolecules·Hyun Woo LeeHoon Kim
Jul 3, 2021·Foods·Sunmin LeeInmyoung Park

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