Inhibition of cytokine production and endothelial expression of adhesion antigens by 5'-methylthioadenosine

European Journal of Pharmacology
M A CerriG Bazzoni

Abstract

We investigated the activity of endogenous nucleoside 5'-deoxy-5'-methylthioadenosine (MTA) on both the production of inflammatory cytokines and the cytokine-dependent endothelial expression of adhesion molecules. The compound inhibited the production of tumor necrosis factor (but not interleukin-1) in lipopolysaccharide-activated macrophages. In addition, MTA selectively inhibited the expression of intercellular adhesion molecule-1 in endothelial cells activated with interleukin-1. This effect was paralleled by a reduction in endothelial adhesiveness for polymorphonuclear leukocytes. These data suggest that MTA might have anti-inflammatory activity.

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Citations

Aug 29, 1996·European Journal of Pharmacology·C D McWhinneyC K Edwards
May 5, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nancy M BenightDouglas G Burrin
Dec 21, 2010·Molecular Microbiology·Nikhat Parveen, Kenneth A Cornell

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