PMID: 7520645May 1, 1994Paper

Inhibition of cytotoxicity of chicken granulocytes by serotonin and ketanserin

Veterinary Immunology and Immunopathology
S I GarssadiI Béládi

Abstract

Serotonin (5-HT) has been observed to impair the cytotoxicity of human natural killer (NK) cells. A study has now been made of the effect of 5-HT on the cytotoxic activity of chicken granulocytes. 5-HT at concentrations of 10(-3) to 10(-6) M inhibited the cytotoxicity of chicken granulocytes when added at the onset of the short-term cytotoxicity assay. Ketanserin, a 5-HT2 receptor antagonist, did not reverse the inhibitory effect of 5-HT on chicken granulocyte cytotoxicity. Moreover, ketanserin at concentrations of 5 x 10(-4) to 5 x 10(-7) M inhibited the cytotoxicity mediated by chicken granulocytes. Pretreatment of the effector cells for 2 h with chick fibroblast interferon reduced the inhibition of chicken NK cytotoxicity induced by 5-HT and by ketanserin. These data indicate that, in birds, the neurotransmitter 5-HT serves as a link between the central nervous system and the immune system, and that interferon can modulate the inhibitory effect of 5-HT on the function of cytotoxic granulocytes.

References

Jan 1, 1990·Developmental and Comparative Immunology·Y MándiI Béládi
Mar 1, 1989·Trends in Pharmacological Sciences·J Linden, T M Delahunty
Oct 2, 1981·Science·R B Herberman, J R Ortaldo

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Citations

Mar 14, 2001·Developmental and Comparative Immunology·P G Merlino, J A Marsh
Apr 25, 2000·International Journal of Antimicrobial Agents·C MiskolciJ Molnár
Sep 13, 2005·In Vitro Cellular & Developmental Biology. Animal·Tibor OláhElisabeth Balint

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