Abstract
Serotonin (5-HT) has been observed to impair the cytotoxicity of human natural killer (NK) cells. A study has now been made of the effect of 5-HT on the cytotoxic activity of chicken granulocytes. 5-HT at concentrations of 10(-3) to 10(-6) M inhibited the cytotoxicity of chicken granulocytes when added at the onset of the short-term cytotoxicity assay. Ketanserin, a 5-HT2 receptor antagonist, did not reverse the inhibitory effect of 5-HT on chicken granulocyte cytotoxicity. Moreover, ketanserin at concentrations of 5 x 10(-4) to 5 x 10(-7) M inhibited the cytotoxicity mediated by chicken granulocytes. Pretreatment of the effector cells for 2 h with chick fibroblast interferon reduced the inhibition of chicken NK cytotoxicity induced by 5-HT and by ketanserin. These data indicate that, in birds, the neurotransmitter 5-HT serves as a link between the central nervous system and the immune system, and that interferon can modulate the inhibitory effect of 5-HT on the function of cytotoxic granulocytes.
References
Feb 1, 1975·European Journal of Immunology·R KiesslingH Wigzell
Jan 1, 1992·International Archives of Allergy and Immunology·K NordlindL Bondesson
Dec 1, 1990·Veterinary Immunology and Immunopathology·R DijkmansA Billiau
Jan 1, 1990·Developmental and Comparative Immunology·Y MándiI Béládi
Mar 1, 1989·Trends in Pharmacological Sciences·J Linden, T M Delahunty
Nov 1, 1988·Journal of Clinical Immunology·E S ArztV E Nahmod
Dec 1, 1988·Journal of Interferon Research·L M FinocchiaroV E Nahmod
May 1, 1987·Immunobiology·Y MándiP Toivanen
Nov 1, 1985·Immunobiology·Y MándiI Béládi
Jul 1, 1974·Thrombosis Research·P S OlsonS E Bergentz
Jan 1, 1981·Journal of Immunological Methods·R HjorthP Vretblad
Oct 1, 1982·In Vitro·O R KaadenB Stiburek
Oct 2, 1981·Science·R B Herberman, J R Ortaldo
Jun 15, 1993·European Journal of Pharmacology·M Rinaldi-CarmonaG Le Fur
Citations
Mar 14, 2001·Developmental and Comparative Immunology·P G Merlino, J A Marsh
Apr 25, 2000·International Journal of Antimicrobial Agents·C MiskolciJ Molnár
Sep 13, 2005·In Vitro Cellular & Developmental Biology. Animal·Tibor OláhElisabeth Balint