Inhibition of deoxyribonucleic acid replication in Bacillus brevis by ribonucleic acid polymerase inhibitors.

Journal of Bacteriology
S Bhattacharya, N Sarkar

Abstract

The incorporation of [3H]thymidine into deoxyribonucleic acid by exponentially growing cells of Bacillus brevis was inhibited by streptolydigin and rifampin in the same concentration range in which these drugs inhibit ribonucleic acid synthesis. Complete inhibition occurred within one-third generation time after drug addition, suggesting an effect on deoxyribonucleic acid chain elongation.

References

Jan 5, 1979·Journal of Molecular Biology·A L Sonenshein, H B Alexander
Jan 20, 1975·Biochemical and Biophysical Research Communications·N Sarkar
Oct 25, 1972·Nature: New Biology·N Sarkar, H Paulus
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J M MackenzieN C Brown
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D BrutlagA Kornberg
Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R OkazakiA Sugino
Feb 29, 1980·Science·N R Cozzarelli
Jan 1, 1980·Annual Review of Biochemistry·T Ogawa, T Okazaki

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