Inhibition of di(2-ethylhexyl) phthalate (DEHP)-induced endocrine disruption by co-treatment of vitamins C and E and their mechanism of action

Journal of Toxicology and Environmental Health. Part a
Seul Min ChoiByung Mu Lee

Abstract

The endocrine disrupting actions of di(2-ethylhexyl) phthalate (DEHP) on testicular functions are postulated to involve excess free radical generation. Thus the aim of this study was to examine the ability of antioxidant vitamins C and E to prevent DEHP-induced testicular disruption in male Sprague-Dawley (SD) rats. SD male rats were administered DEHP alone or DEHP with vitamin C and/or vitamin E for 30 days. DEHP alone increased the levels of testosterone (T) and reduced estradiol (E2) concentrations. Supplementation with antioxidant vitamins diminished or restored serum T levels noted in DEHP-treated rats to control values. In contrast vitamins C and E increased E2 levels to control in rats administered DEHP. Antioxidants significantly improved the decreased testicular levels of reduced glutathione and activity of superoxide dismutase compared to DEHP-treatment alone. Co-treatment of vitamins C and E also markedly improved the reduced epididymal sperm head counts and elevated levels of malondialdehyde (MDA) or 8-hydroxydeoxyguanosine (8-OHdG) induced by DEHP treatment. These results support the concept that the adverse actions of DEHP may be related to increased free radical generation while co-treatment with vitamins C and E...Continue Reading

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Citations

Nov 13, 2018·Journal of Toxicology and Environmental Health. Part a·Dong Hyun KimByung-Mu Lee
Apr 10, 2019·Journal of Toxicology and Environmental Health. Part a·Bu Young ChungByung-Mu Lee
Jul 31, 2020·Journal of Toxicology and Environmental Health. Part a·Chi Rim SungSeung Jun Kwack
Feb 13, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Khaled HabasDiana Anderson
Feb 12, 2021·Antioxidants·Carmen MannucciSebastiano Gangemi
Jun 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Soheila SafarpourFarideh Feizi

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Methods Mentioned

BETA
light microscopy
MDA

Software Mentioned

Minitab
SPSS

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