Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation.

Learning & Memory
Katja MerschbaecherUli Mueller

Abstract

Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied garcinol, an inhibitor of the HATs of the p300 (EP300 binding protein)/CBP (CREB-binding protein) family, and the HATs of the PCAF (p300/CBP-associated factor) family. As comparative agent we applied C646, a specific inhibitor that selectively blocks HATS of the p300/CBP family. Immunochemical analysis reveals differences in histone H3 acetylation in the honeybee brain, in response to the injection of either C646 or garcinol. Behavioral assessment reveals that the two drugs cause memory impairment of different nature when injected after associative conditioning: processes disturbed by garcinol are annihilated by the established transcription blocker actinomycin D and thus seem to require transcription processes. Actions of C646 are unaltered by actinomycin D, and thus seem to be independent of transcription. The outcome of our different approaches as summarized suggests that distinct HATs c...Continue Reading

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H M Sobell
Aug 23, 2008·Science·Gregory A HorwitzArnold J Berk
Sep 23, 2008·The International Journal of Biochemistry & Cell Biology·Stephanie SpangeOliver H Krämer
Jul 7, 2009·Drug Discovery Today·Frank J Dekker, Hidde J Haisma
Mar 12, 2010·Neuroscience and Biobehavioral Reviews·Shiv K Sharma
Sep 14, 2010·Biochimica Et Biophysica Acta·B Ruthrotha SelviAnne-Laurence Boutillier
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ruth M BarrettMarcelo A Wood
Apr 28, 2011·Neurobiology of Learning and Memory·Susan C McQuown, Marcelo A Wood
May 7, 2011·Neurobiology of Learning and Memory·Stephen J Haggarty, Li-Huei Tsai
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roger MarekTimothy W Bredy
Dec 2, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Farah D LubinRobin L Davis
Mar 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zaorui ZhaoKaryn M Frick
Nov 24, 2012·Biopolymers·Hua Yuan, Ronen Marmorstein
Jan 17, 2013·Learning & Memory·Iva B ZovkicJ David Sweatt
Jun 8, 2013·The FEBS Journal·David R Friedmann, Ronen Marmorstein
Sep 24, 2013·JAK-STAT·Celine S NicolasStephane Peineau
Oct 1, 2013·Pharmacological Reviews·Deepak P SrivastavaPeter Penzes
Oct 15, 2013·Molecular Neurobiology·Wanda M SnowBenedict C Albensi
Dec 24, 2014·Trends in Neurosciences·Nicolas PanayotisMike Fainzilber
Jul 21, 2015·Epigenetics & Chromatin·Malaina GaddisPeggy J Farnham

❮ Previous
Next ❯

Citations

Jul 19, 2016·Journal of Neuroscience Research·Jie ZhuTeng Chen
May 16, 2020·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Alena B ZuzinaPavel M Balaban
Aug 7, 2019·Chemistry & Biodiversity·Rainer Schobert, Bernhard Biersack
Jan 31, 2020·Frontiers in Behavioral Neuroscience·Melissa S MonseyJane R Taylor
Feb 27, 2020·Cell Reports·Maria Eugenia VillarMartin Giurfa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.