PMID: 2497075May 15, 1989Paper

Inhibition of DMBA-induced mammary tumorigenesis by caloric restriction in rats fed high-fat diets

International Journal of Cancer. Journal International Du Cancer
D M KlurfeldD Kritchevsky

Abstract

Most previous studies on the inhibiting effect of caloric restriction during promotion of DMBA-induced mammary carcinogenesis have used low to moderate levels of dietary fat, i.e., about 4 to 14% by weight. The current study was designed to test whether a moderate degree of caloric restriction, 25%, would inhibit tumor growth in rats fed the equivalent of 20% dietary fat which approximates human consumption in affluent countries. Rats were fed diets ad libitum that contained 5, 15 or 20% corn oil. Groups of rats were pair-fed to the last 2 groups, but subjected to a 25% caloric restriction. These groups were fed 20 or 26.7% corn oil so that absolute fat intake in the paired groups was identical. Significant inhibition of tumor incidence, tumor weight, tumor burden, body fat deposition, and fasting serum insulin were observed in the 2 calorically restricted groups. We conclude that moderate caloric restriction is significantly more effective in inhibiting tumor growth than is the promoting effect of diets high in fat. Total body weight, body fat and serum insulin concentrations may be better correlates of risk of developing mammary tumors than is dietary fat.

References

Apr 1, 1986·Lipids·D KritchevskyD M Klurfeld
Feb 1, 1988·Japanese Journal of Cancer Research : Gann·I KatoT Suzuki
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·F de Waard, D Trichopoulos
Jun 15, 1987·International Journal of Cancer. Journal International Du Cancer·M BethD Schmähl
Jan 1, 1987·The New England Journal of Medicine·W C WillettF E Speizer
Jan 1, 1984·Advances in Cancer Research·T Byers, S Graham

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Citations

Oct 1, 1992·Lipids·K K Carroll
Nov 1, 1993·Mutation Research·D Kritchevsky
Dec 1, 1993·Mutation Research·Z Djuric, D Kritschevsky
Mar 28, 1998·Breast Cancer Research and Treatment·D Kritchevsky
Jan 1, 1991·Nutrition and Cancer·K K Carroll, H I Parenteau
May 29, 2002·Hybridoma and Hybridomics·David Kritchevsky
Sep 20, 2005·Breast Cancer Research : BCR·Reza HakkakSoheila Korourian
Dec 2, 2005·Breast Cancer Research and Treatment·Stephanie A Navarro SilveraThomas E Rohan
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C J ArtsJ H Thijssen
May 14, 2010·Biochimica Et Biophysica Acta·Shanchun GuoRuben R Gonzalez-Perez
Oct 5, 2007·Ageing Research Reviews·Mark P Mattson
Jan 5, 2002·Nutrition and Cancer·Z DjuricR W Hart
Aug 1, 1993·Cancer·D Kritchevsky
Mar 29, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·A B de VasconcelosR Sichieri
Sep 15, 1990·Cancer·D Kritchevsky
Feb 1, 1993·The Proceedings of the Nutrition Society·D Kritchevsky
Nov 11, 2003·The Journal of Nutrition·David Kritchevsky
May 1, 1997·The Journal of Nutrition·A E Rogers

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