Inhibition of DNA alkylation damage with inorganic salts

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Elizabeth E Hamilton, Jonathan J Wilker

Abstract

Human exposure to alkylating agents metabolized from tobacco- and food-borne carcinogens occurs regularly. Dietary inorganic compounds such as selenium and vanadium have been shown previously to provide chemoprotective benefits in rat and human trials. Here, we present biochemical data on the ability of inorganic compounds to protect DNA from alkylation damage. An enzyme cleavage assay is used to observe alkylated DNA. Simple salts (e.g., NaCl or NiCl(2)) did not prevent DNA alkylation, whereas anionic oxo species (e.g., Na(2)SeO(4) or Na(3)VO(4)) did inhibit alkylation. We propose that these oxo species behave as nucleophilic targets for the electrophilic alkylating agents, thereby preventing DNA damage.

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Citations

Jul 16, 2010·Cell Biochemistry and Biophysics·Ria R Ramoutar, Julia L Brumaghim
Jun 27, 2012·Journal of Biomolecular Structure & Dynamics·Reza SilaviAli Akbar Saboury
Nov 7, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anikó Németh, Mihály Dernovics
Jul 11, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Tridib ChakrabortyMalay Chatterjee
Apr 7, 2021·Journal of Inorganic Biochemistry·Kahoana PostalGiovana G Nunes
Jan 24, 2012·Journal of Inorganic Biochemistry·Giovana G NunesEmanuel M de Souza

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