Inhibition of dorsal-horn cell responses by stimulation of the Kölliker-Fuse nucleus

Journal of Neurosurgery
C J HodgeR T Stevens

Abstract

The Kölliker-Fuse nucleus (KF) in the dorsolateral pons has been shown to be the major source of catecholamine innervation of the spinal cord. This has important implications in terms of pain control mechanisms, since catecholamine-mediated mechanisms are essential for the expression of opiate and other varieties of antinociception. This study examines the effects of KF stimulation on responses of dorsal-horn cells to innocuous and noxious cutaneous stimuli in anesthetized cats. Stimulation of the KF potently inhibits the responses of dorsal-horn cells to both noxious and innocuous stimuli. The threshold for the inhibitory effect is significantly lower for responses to noxious stimuli as opposed to innocuous stimuli. The inhibitory effect is specific to the stimulus site, as evidenced by a marked decrease in the effect following small changes in the position of the stimulating electrode in the brain stem. The latency of the effects indicates a bulbospinal conduction velocity of 4 to 5 m/sec, which is much slower than usual reticulospinal effects and is consistent with a catecholamine-mediated system. The dependence of KF-spinal inhibition on intact biogenic amines was tested by depleting the animals of these amines with reserpi...Continue Reading

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Citations

Jan 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·W D Willis, K N Westlund
Oct 5, 2010·Neurologia Medico-chirurgica·Hideki Oshima, Yoichi Katayama
May 24, 2015·Neurosurgical Review·Olaf E M G SchijnsPeter J Koehler
Mar 25, 2011·Journal of Neurophysiology·Yeechan WuMing-Yuan Min
Dec 8, 2004·The European Journal of Neuroscience·S Nag, S S Mokha

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