Inhibition of drug-induced anorexia in rats by methysergide
Iproniazid was found to reduce food consumption in fasting rats. Combined treatment of iproniazid with tryptophan resulted in a significantly greater anorexic action whilst tryptophan alone had no effect on food consumption. Iproniazid treatment was associated with a significant increase in brain 5-hydroxytryptamine (5-HT) concentration but in association with tryptophan higher brain 5-HT concentrations were recorded. The anorexic action of the iproniazid-tryptophan combination was antagonized in a dose-dependent fashion by methysergide. Equivalent levels of anorexia induced by fenfluramine and mazindol were similarly antagonized by methysergide in a dose-related manner. The results suggest a common role of 5-HT in the inhibition of eating behaviour in fasting rats when anorexia is induced by iproniazid, fenfluramine or mazindol, sensitive to a specific 5-HT antagonist.
Simulation of the apparent effects of mebanazine on growth hormone by pair-feeding of control animals
Antagonism by methysergide of the 5-hydroxytryptamine-like action of toxic doses of fenfluramine in dogs
Effects of -methoxy derivatives of 3-trifluoromethylphenylethylamine on food intake and brain serotonin content
The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine
Feeding parameters with two food textures after chlordiazepoxide administration, alone or in combination with d-amphetamine or fenfluramine
Food intake and rumen motility in dwarf goats. Effects of some serotonin receptor agonists and antagonists
Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype
Evidence for the effect of tryptophan on the pattern of food consumption in free feeding and food deprived rats
Serotonergic influences on food intake: effect of 5-hydroxytryptophan on parameters of feeding behaviour in deprived and free-feeding rats
Serotonin depletion by 5,7-dihydroxytryptamine or para-chloroamphetamine does not affect cancer anorexia
Differential effects of pharmacological agents acting on monoaminergic systems on drug-induced anorexia
Effects of mesulergine treatment on diet selection, brain serotonin (5-HT) and dopamine (DA) turnover in free feeding rats
Environmental, toxicological and related aspects of tryptophan metabolism with particular reference to the central nervous system
Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.