PMID: 2658Dec 1, 1975

Inhibition of drug-induced anorexia in rats by methysergide

The Journal of Pharmacy and Pharmacology
A M Barrett, L McSharry

Abstract

Iproniazid was found to reduce food consumption in fasting rats. Combined treatment of iproniazid with tryptophan resulted in a significantly greater anorexic action whilst tryptophan alone had no effect on food consumption. Iproniazid treatment was associated with a significant increase in brain 5-hydroxytryptamine (5-HT) concentration but in association with tryptophan higher brain 5-HT concentrations were recorded. The anorexic action of the iproniazid-tryptophan combination was antagonized in a dose-dependent fashion by methysergide. Equivalent levels of anorexia induced by fenfluramine and mazindol were similarly antagonized by methysergide in a dose-related manner. The results suggest a common role of 5-HT in the inhibition of eating behaviour in fasting rats when anorexia is induced by iproniazid, fenfluramine or mazindol, sensitive to a specific 5-HT antagonist.

References

Apr 1, 1975·British Journal of Pharmacology·W BuczkoS Garattini
Dec 1, 1973·European Journal of Pharmacology·B V Clineschmidt
Aug 1, 1970·The Journal of Pharmacy and Pharmacology·S Jespersen, J Scheel-Krüger
Jun 1, 1971·The Journal of Pharmacy and Pharmacology·W H FunderburkJ W Ward
Nov 14, 1973·Nature: New Biology·Z L Kruk
Nov 1, 1972·The Journal of Clinical Pharmacology and New Drugs·A J Hadler
Jan 1, 1971·British Journal of Pharmacology·E CostaA Revuelta
May 1, 1965·Biochemical Pharmacology·S H SnyderM Zweig
Jun 1, 1959·British Journal of Pharmacology and Chemotherapy·M K PAASONEN, N T KARKI

Citations

Jan 1, 1989·Psychopharmacology·J C Neill, S J Cooper
Jan 1, 1987·Psychopharmacology·J D Leander
Jan 1, 1995·Psychopharmacology·D N Velázquez MartínezJ E Villarreal
May 15, 1977·European Journal of Pharmacology·R SamaninS Garattini
Jan 12, 1988·European Journal of Pharmacology·G HewsonJ Hughes
Jul 21, 1994·European Journal of Pharmacology·K NagaiH Nakagawa
Feb 1, 1984·Physiology & Behavior·J C PetersA E Harper
Aug 1, 1981·Pharmacology, Biochemistry, and Behavior·J L GibbonsS F Leibowitz
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·W T ChanceJ E Fischer
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·W T ChanceJ E Fischer
Jan 1, 1983·Molecular Aspects of Medicine·D A Bender
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·W T ChanceJ E Fischer
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
Jan 1, 1980·Progress in Neuro-psychopharmacology·B V Clineschmidt, P R Bunting
Sep 2, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·G GiannakopoulosC Couvaris
Oct 1, 1987·Alcoholism, Clinical and Experimental Research·K Gill, Z Amit
Sep 1, 1978·The Proceedings of the Nutrition Society·A M Barrett

Related Concepts

Anorexia
Desire for Food
Brain Chemistry
Ingestion
Pondimin
Iproniazid
Solucaps
Sansert
Hydroxytryptamine
PMS-Tryptophan

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.