PMID: 3749813Aug 1, 1986Paper

Inhibition of drug-induced eosinophilia by cyclosporin A

Scandinavian Journal of Immunology
A W ThomsonJ G Simpson

Abstract

Administration of cyclophosphamide to Sprague-Dawley rats 2 days before immunization with ovalbumin in complete Freund's adjuvant resulted in a striking blood, bone marrow, and tissue eosinophilia. The number of circulating eosinophils reached a maximum (50-fold increase above normal) 2 weeks after immunization, and eosinophils were also prominent in bone marrow, lymph nodes (paracortical areas), spleen (white and red pulp), and liver. The eosinophilia could be inhibited by daily oral administration of cyclosporin A (CsA), although its effect was dependent both on the duration of treatment and on the dosage of CsA. A similar, inhibitory action of CsA was demonstrated with respect to methotrexate-induced eosinophilia. This experimental model may prove useful in the study of factors regulating eosinophil production and in examining the prospective value of CsA in the treatment of conditions where eosinophils play a central role.

References

Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Apr 1, 1976·Zeitschrift Für Immunitätsforschung, Experimentelle Und Klinische Immunologie·R LynenL Dieminger
Jun 1, 1970·The Journal of Experimental Medicine·A Basten, P B Beeson
Jan 1, 1982·Immunological Reviews·J L Turk, D Parker
May 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B D Kahan

❮ Previous
Next ❯

Citations

Dec 1, 1993·International Journal for Parasitology·K YoshimuraK Unno
Jan 12, 1999·Journal of the European Academy of Dermatology and Venereology : JEADV·R E SchopfM Bräutigam
May 1, 1996·Experimental Lung Research·I S LossosR Breuer
Jul 1, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·F RäßlerP Elsner
Nov 1, 1994·The British Journal of Dermatology·S TaniguchiT Hamada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.