Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants

Scientific Reports
Manju SharmaShouxiong Huang

Abstract

Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants. To test this notion, we determined whether the common lipophilic pollutants benzo[a]pyrene and diesel exhaust particles impact on the activation of lipid-specific T cells. Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations. Similarly, diesel exhaust particles showed a marginal inhibitory effect. Using transcriptomic profiling, we discovered that the gene expression for regulating endocytic and lipid metabolic pathways was perturbed by benzo[a]pyrene. Imaging flow cytometry also showed that CD1a and CD1d proteins were retained in early and late endosomal compartments, respectively, supporting an impaired endocytic lipid antigen presentation for T cell activation upon benzo[a]pyrene exposure. This work conceptually demonstrate...Continue Reading

References

Oct 24, 2002·Blood·Kelli P A MacDonaldDerek N J Hart
Jan 4, 2003·Nature Reviews. Immunology·D Branch Moody, Steven A Porcelli
Mar 23, 2004·Annual Review of Immunology·Manfred Brigl, Michael B Brenner
Jun 11, 2004·Biophysical Journal·Sylvain V CostesStephen Lockett
Dec 8, 2004·The Journal of Experimental Medicine·Mi-Kyung ChangJoseph L Witztum
Oct 7, 2005·Nature·Peter van den ElzenMichael B Brenner
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manfred BriglJenny E Gumperz
Sep 20, 2006·The Journal of Experimental Medicine·Stephan D GadolaVincenzo Cerundolo
Oct 24, 2007·Current Opinion in Structural Biology·Dirk M Zajonc, Mitchell Kronenberg
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Apr 30, 2008·The Journal of Experimental Medicine·Shouxiong HuangTed H Hansen
May 13, 2008·Environmental Health Perspectives·Hyunok ChoiFrederica P Perera
Nov 4, 2008·Mutation Research·Sandra E Gomez-MejibaDario C Ramirez
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Weiming YuanPeter Cresswell
May 6, 2009·PloS One·Daryl CoxWilliam Hildebrand
Dec 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela CernadasMichael B Brenner
Nov 3, 2010·Nature Immunology·Annemieke de JongD Branch Moody
Dec 4, 2010·Occupational and Environmental Medicine·Hueiwang Anna JengMing-Tsang Wu
Jan 20, 2011·European Journal of Immunology·Claudia de LallaGiulia Casorati
Jun 1, 2011·The Journal of Experimental Medicine·Gerhard WingenderAnthony A Horner
Jul 27, 2011·Analytical and Bioanalytical Chemistry·Gudrun Nürenberg, Dietrich A Volmer
Nov 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shouxiong HuangD Branch Moody
Nov 22, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Su Young ChiSung Chul Lim
Jun 5, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yongna XingChristopher A Bradfield
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Jun 30, 2012·Nature Methods·Kevin W EliceiriAnne E Carpenter
Jan 22, 2013·Nature Reviews. Immunology·Patrick J BrennanMichael B Brenner
Feb 22, 2013·Nature·Médéric DiardWolf-Dietrich Hardt
Mar 27, 2013·The Journal of Experimental Medicine·Dalam LyD Branch Moody
Sep 26, 2013·The Journal of Allergy and Clinical Immunology·Eric B BrandtGurjit K Khurana Hershey
Dec 24, 2013·Nature Immunology·Annemieke de JongD Branch Moody
Jan 11, 2014·Environmental Research·Kyung Hwa JungRachel L Miller
Jan 28, 2014·The Journal of Clinical Investigation·Yoko Kidani, Steven J Bensinger
Nov 1, 2012·Current Immunology Reviews·Rachael VialeVipin Kumar
Feb 24, 2015·Immunological Reviews·Ildiko Van Rhijn, D Branch Moody
May 6, 2015·Cancer Immunology Research·Rosanna M McEwen-SmithVincenzo Cerundolo
Jun 25, 2015·Carcinogenesis·Patricia A ThompsonWilliam H Bisson
Jul 16, 2015·Frontiers in Immunology·Sarah SiddiquiChyung-Ru Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
reverse transcription PCR
PCR
chip

Software Mentioned

Cytoscape
Flowjo
IDEAS
Primer
ToppCluster
- BLAST
Fiji
ImageJ
edgeR Bioconductor

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Postȩpy higieny i medycyny doświadczalnej
Joanna E Mikulska
Nature Reviews. Immunology
D Branch Moody, S A Porcelli
CA: a Cancer Journal for Clinicians
H Frumkin, M J Thun
© 2022 Meta ULC. All rights reserved