PMID: 11322451Apr 27, 2001Paper

Inhibition of endothelin-converting enzyme activity in the rabbit basilar artery

Neurosurgery
Michael ZimmermannVolker Seifert

Abstract

Endothelin (ET)-1 may be involved in the regulation of cerebrovascular resistance under pathological conditions, most notably during the development of vasospasm after subarachnoid hemorrhage. Blocking ET-converting enzyme activity may be a promising approach to the prevention of cerebral vasospasm after subarachnoid hemorrhage. In this study, the effects of several putative ET-converting enzyme inhibitors were investigated after intracisternal application in rabbits, to inhibit basilar artery contractions induced by big ET-1 (2 x 10(-6) mol/L). In the group pretreated with [D-Val22]big ET-1[16-38] (2 x 10(-5) mol/L) (n = 8), the angiographically measured diameter of the basilar artery changed from 0.63 +/- 0.12 mm to 0.66 +/- 0.12 mm. In the control group (n = 8), the diameter of the basilar artery decreased from 0.71 +/- 0.13 mm to 0.57 +/- 0.15 mm. These results corresponded to an increase in vessel diameter of 5 +/- 10% in the treatment group and a decrease in vessel diameter of 20 +/- 16% in the control group (P = 0.014). In the group pretreated with captopril (2 x 10(-4) mol/L) (n = 8), the angiographically measured diameter of the basilar artery changed from 0.64 +/- 0.11 mm to 0.71 +/- 0.10 mm. These results corresponde...Continue Reading

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Citations

Apr 3, 2003·Clinical Neuropharmacology·Hartmut VatterVolker Seifert
Aug 13, 2005·Critical Care Medicine·Manuel Ruiz-BailénUNKNOWN ARIAM Group
Jun 5, 2003·The Journal of Physiology·Yakhin Shimoni, Xiu-Fang Liu

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