PMID: 7538038Dec 1, 1994Paper

Inhibition of endothelium-dependent vasodilation by Escherichia coli endotoxemia

Shock
J L ParkerH R Adams

Abstract

To test the hypothesis that release of endothelium-derived relaxing factor/nitric oxide is inhibited by Gram-negative lipopolysaccharide (LPS; endotoxin), we examined endothelium-independent and endothelium-dependent vasodilator agents in aortic vascular smooth muscle isolated from guinea pigs 4 h after injection of saline (controls) or induction of Escherichia coli endotoxemia. LPS significantly inhibited vasodilator responses to the endothelium-dependent agonists acetylcholine (ACh; 10(-10)-10(-5) M) and ADP (10(-8)-10(-5) M). However, LPS did not affect vasodilator responses to the endothelium-independent agonist nitroprusside (10(-10)-10(-4) M). The nitric oxide synthase (NOS) inhibitor N gamma-nitro-L-arginine methyl ester (L-NAME) inhibited the vasodilator response to ACh; whereas, the cyclooxygenase inhibitor indomethacin (INDO) did not reduce vasodilator effects of ACh. Neither L-NAME nor INDO affected the vasodilator effects of nitroprusside in LPS or control vessels. In contrast, L-NAME converted the vasodilator action of ADP to a vasoconstrictor response that was blocked individually by INDO and the thromboxane synthase inhibitor dazoxiben, suggesting that ADP releases NO and also the vasoconstrictor and platelet agg...Continue Reading

Citations

Sep 27, 2002·Toxicology·Susana Cadenas, Ana M Cadenas
Sep 22, 2007·Critical Care Medicine·Yvette C Luiking, Nicolaas E P Deutz
Jul 1, 2005·Shock·Carson C ChowYoram Vodovotz
Aug 17, 2006·Shock·Yoram VodovotzGilles Clermont
Apr 28, 2010·Journal of Cardiovascular Pharmacology·Michel FélétouTony J Verbeuren
Sep 16, 2011·Journal of Hypertension·Jagadeesha K DammanahalliZhongjie Sun
Jun 12, 2013·Critical Care : the Official Journal of the Critical Care Forum·Corinna LuppMartin Westphal
Jun 28, 2003·American Journal of Veterinary Research·Mohamed Y MallemJean-Claude Desfontis
Sep 10, 1998·Nitric Oxide : Biology and Chemistry·S S GreenbergT D Giles
Aug 11, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C A GunnettD D Heistad
Mar 25, 2009·Current Opinion in Anaesthesiology·Lindsay-Rae B WeitzelPaul E Wischmeyer
Jan 7, 2000·Anesthesia and Analgesia·P T MurrayJ G Umans
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C A GunnettF M Faraci
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C A GunnettF M Faraci
Dec 9, 1998·The American Journal of Physiology·T SaetreA O Aasen

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