Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons

Neuroscience Letters
Jianguo LiCe Zhang

Abstract

Hippocampal CA1 pyramidal neurons are sensitive to ischemic damage. However, the cellular and molecular mechanisms underlying neuronal cell death caused by ischemia-reperfusion (I/R) are not completely clear. Here, we report that the ephrinA/EphA cell-cell interaction signaling pathway plays an important role in the apoptosis of hippocampal CA1 pyramidal neurons induced by I/R. We found that the expression of ephrinA3 and EphA4 is increased in the CA1 region following transient forebrain ischemia. Blocking ephrinA3/EphA4 interaction by EphA4-Fc, an inhibitor of EphA4, attenuated apoptotic neuronal cell death, likely through the inhibition of caspase-3 activation. These results reveal a novel function of ephrin/Eph signaling in the regulation of apoptosis in CA1 pyramidal neurons after I/R.

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Citations

Feb 4, 2014·Future Neurology·Kellie Park, Thomas Biederer
May 17, 2018·Apoptosis : an International Journal on Programmed Cell Death·Mustapha Kandouz
Jun 18, 2020·Journal of Pain Research·Min-Ji KimDong-Kuk Ahn
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Feb 6, 2021·Neurological Research·Yin WangLin Jiang

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Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Apoptosis

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