Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain

Neurosurgery
P L PenarT R Tritton

Abstract

Glioblastoma multiforme is a malignant primary brain tumor associated with short patient survival despite aggressive treatment, in part because of its propensity to aggressively infiltrate into brain tissue. Glioblastoma multiforme is also unique because it is the only nonepithelial human tumor for which excessive activation of epidermal growth factor receptor (EGFR) has been consistently linked to tumor growth and patient survival, and EGFR activation promotes glioblastoma multiforme infiltration in vitro. Cocultures of human glioblastoma spheroids (derived from three separate patients) and fetal rat brain aggregates were examined for infiltration using confocal microscopy, in the presence of 0 to 100 mumol/L genistein, a tyrosine kinase (TK) inhibitor, and 3 mumol/L tyrphostin A25, a specific EGFR-TK inhibitor. Infiltration (not attachment) was completely inhibited by genistein at 10 mumol/L, the IC20 for monolayer growth inhibition in two cell lines. Tyrphostin A25 at 3 mumol/L (the IC20 for monolayers) reduced invasion in a third cell line from 38.8 +/- 6.1% invasion-hour per hour (n = 5) to 2.9 +/- 1.2% invasion-hour per hour (n = 6) (P = 0.0002, two-tailed t test, 93% inhibition), and from 0.54 +/- 0.065% per hour (slope)...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L W BradyP Black
Jan 1, 1992·Journal of Neuropathology and Experimental Neurology·M R HurttJ Locker
Sep 1, 1992·Neuron·J Schlessinger, A Ullrich
May 1, 1992·Mutation Research·G N Fuller, S H Bigner
Jan 1, 1992·Journal of Endocrinological Investigation·A Di CarloV Macchia
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M ChaffanetA L Benabid
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J EkstrandV P Collins
Nov 22, 1991·Science·S A Aaronson
Feb 1, 1991·British Journal of Cancer·N L TuziW J Gullick
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A HumphreyD D Bigner
May 1, 1991·Journal of Electron Microscopy Technique·G J SmithK B Pryzwansky
Jan 1, 1990·Acta Neuropathologica·O EngebraatenO D Laerum
Sep 1, 1990·Biochemical Pharmacology·A Levitzki
Mar 1, 1990·Journal of Neurosurgery·R BjerkvigE O Backlund
May 9, 1988·Journal of Immunological Methods·J R GlenneyM P Kamps
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·G ReifenbergerW Wechsler
Apr 1, 1987·Carcinogenesis·K T KelseyJ B Little
Apr 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R BjerkvigO D Laerum
Apr 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R Bjerkvig
Feb 1, 1994·Journal of Neurochemistry·D L FeinsteinD J Reis
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S KoochekpourG J Pilkington
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T FotsisL Schweigerer
Sep 1, 1994·Journal of Pharmaceutical Sciences·V S ParmarM M Mareel

❮ Previous
Next ❯

Citations

Jun 28, 2000·Progress in Neurobiology·M P Junier
Oct 18, 2000·Critical Reviews in Oncology/hematology·W Mueller-Klieser
May 12, 2004·Nature Reviews. Drug Discovery·Jeremy N Rich, Darell D Bigner
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel ParisMichael Mullan
Jan 10, 2002·Biochemical and Biophysical Research Communications·A El-ObeidMonica Nistér
Jan 1, 1997·Acta neurochirurgica·E Van de Kelft
Nov 21, 2007·Expert Review of Anticancer Therapy·Andrew ChiPatrick Y Wen
Oct 30, 2007·Neurologic Clinics·Claire M SauvageotCharles D Stiles
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·Birgit GeoergerGilles Vassal
Nov 3, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Andrew P Morokoff, Ulrike Novak
Mar 25, 2015·Journal of Medical Internet Research·Assaf GottliebRuss B Altman
Jul 18, 2009·Journal of Korean Neurosurgical Society·Se Youn JangJohn G Frazee
Sep 1, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kelly L MooneyIsaac Yang
Dec 13, 2000·The Journal of Pathology·M MonaghanD McCormick
Jun 21, 2017·International Journal of Molecular Sciences·Stefanie Keller, Mirko H H Schmidt
Oct 2, 2017·Journal of Neurointerventional Surgery·Satoshi KiyofujiWaleed Brinjikji
Mar 4, 2017·AJNR. American Journal of Neuroradiology·W BrinjikjiD F Kallmes
Nov 20, 2010·AJNR. American Journal of Neuroradiology·A J MartinD Saloner
Jul 9, 2009·Cancer Prevention Research·Elena P Moiseeva, Margaret M Manson
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tobias MartensKatrin Lamszus
Feb 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander SchulteKatrin Lamszus
Aug 2, 2021·Cellular and Molecular Life Sciences : CMLS·Mariana MedeirosMaría Sol Brassesco
Aug 7, 2021·Journal of Neurointerventional Surgery·Philippe DodierGerhard Bavinzski
Aug 14, 2021·AJNR. American Journal of Neuroradiology·A AlwakealM B Potts

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