Inhibition of episomal hepatitis B virus DNA in vitro by 2,4-diamino-7- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-pyrrolo[2,3-d]pyrimidine.

Antimicrobial Agents and Chemotherapy
J O OjwangR F Rando

Abstract

The nucleoside analog 2,4-diamino-7-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)pyrrolo[2,3-d]pyrimidine (T70080) and several related compounds were evaluated for anti-hepatitis B virus (HBV) activity by using cultured 2.2.15 cells. T70080 reduced episomal viral replication in these cells by 50% at a concentration of 0.7 microgram/ml. At the same time, T70080 reduced cellular proliferation by 50% at a concentration in excess of 100 micrograms/ml, yielding a therapeutic index of > 143. In cells cultured for 12 days in the presence of 10 or 50 micrograms of T70080 per ml and then with drug-free medium, for an additional 12 days, viral DNA replication was completely inhibited initially but resumed between 6 and 12 days post-drug removal. In view of the potent anti-HBV activity shown, T70080 is a good candidate for further evaluation as a treatment of human HBV infection.

References

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L DoongY C Cheng
Mar 1, 1991·Antiviral Research·B E Korba, G Milman
Feb 1, 1991·Antimicrobial Agents and Chemotherapy·T YokotaE De Clercq
Feb 1, 1991·Revue de l'infirmière·A Montloin
Mar 1, 1990·Journal of Medicinal Chemistry·V E MarquezJ S Driscoll
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·E MatthesW E Müller
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L Davis, J H Hoofnagle
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P M PriceG Acs
Oct 10, 1985·Nature·P TiollaisA Dejean
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A SellsG Acs
Nov 15, 1988·Biochemical and Biophysical Research Communications·S SuzukiD L Tyrrell

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Citations

Jul 1, 1996·Baillière's Clinical Gastroenterology·G M Dusheiko

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