Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine

British Journal of Clinical Pharmacology
D K RobbinsS L Chang

Abstract

The effect of valproic acid (VPA) on the disposition of carbamazepine-10,11-epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide.

References

May 1, 1988·British Journal of Clinical Pharmacology·F PisaniL Bertilsson
Feb 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·E Mendez-AlvarezG Sierra-Marcuño
Jan 1, 1985·Clinical Pharmacokinetics·M EichelbaumL Bertilsson
Jan 1, 1983·Clinical Pharmacology and Therapeutics·T TomsonL Bertilsson
Jan 1, 1981·Therapeutic Drug Monitoring·L McKaugeM J Eadie

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Citations

Jun 1, 1994·Annals of Neurology·E L SoK W Weatherford
Mar 1, 1994·Journal of Clinical Pharmacology·S M TangeP E Senécal
Jan 20, 2010·Journal of Pharmacokinetics and Pharmacodynamics·M MarchandD J Critchley
Jul 31, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M BattM M Galteau
Mar 23, 1999·Pharmaceutica acta Helvetiae·K M MatarA Tekle
Apr 16, 1998·Surgical Neurology·S R Winkler, M S Luer
Apr 15, 2009·The Journal of Pharmacology and Experimental Therapeutics·Xi YangCurtis J Omiecinski
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Christophe Morisseau, Bruce D Hammock
Aug 11, 2000·Pharmacotherapy·W R Garnett
Aug 8, 1991·Biochemical Pharmacology·S L WangJ D Huang
Feb 18, 1992·Biochemical Pharmacology·D K RobbinsH Thomas
Dec 2, 2004·The Journal of Pharmacology and Experimental Therapeutics·Ann-Charlotte EgnellC Scott Boyer
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Ann-Charlotte EgnellScott Boyer
Feb 1, 1997·Therapeutic Drug Monitoring·J C DeToledoR E Ramsay
Jul 23, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Eyal SobolMeir Bialer
Jan 9, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Natasa DjordjevicJasmina R Milovanovic

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