PMID: 9163904May 1, 1997Paper

Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole

FEMS Microbiology Letters
T KuchtaN J Russell

Abstract

The antifungal agent 6-amino-2-n-pentylthiobenzothiazole at a concentration of 40 microM lowered the specific growth rate of exponentially growing cultures of Saccharomyces cerevisiae by 36%. Treatment with 6-amino-2-n-pentylthiobenzothiazole inhibited the biosynthesis of ergosterol and caused an accumulation of the methylated sterol precursors ergosta-5,7-dienol and squalene, but had no significant effect on the composition and the rate of biosynthesis of fatty acids. The results indicate that neither the inhibition of ergosterol biosynthesis, nor the slowing-down of culture growth by this antifungal agent, led to a compensatory alteration in the pattern of fatty-acyl chains in membrane lipids. This finding contradicts the accepted wisdom for the action of a number of antifungal agents.

References

Dec 21, 1977·Biochimica Et Biophysica Acta·R A Gonzales, L W Parks
Jan 24, 1975·Biochimica Et Biophysica Acta·N N Ragsdale
Jan 1, 1987·Antimicrobial Agents and Chemotherapy·N H GeorgopapadakouP T Funke

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Citations

Dec 15, 2010·Pathology Research International·John Provias, Brian Jeynes
Oct 4, 2011·Journal of Neurosurgery·Daniel D CavalcantiMark C Preul
Sep 26, 2002·Journal of Neurosurgery·Stacey A WoodsAbhijit Guha
Mar 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvain DarnetHubert Schaller
May 16, 2000·Veterinary Pathology·S DunihoA Koestner

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