Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators

Molecular Carcinogenesis
R Fuchs-YoungC Walker

Abstract

Uterine leiomyoma is the most frequent gynecologic neoplasm in women. By using a panel of cell lines derived from spontaneous Eker rat leiomyomas, we examined the estrogen-responsive phenotype of these tumor cells. Leiomyoma-derived ELT cell lines proliferated in response to estrogen, and estrogen-induced cell proliferation could be inhibited by the estrogen antagonist ICI 182780 and the selective estrogen-receptor modulators (SERMs) raloxifene and tamoxifen. In addition to inhibiting cell growth, these antagonists also inhibited estrogen-induced increases in progesterone-receptor expression. These data indicate that SERMs such as raloxifene and tamoxifen act as estrogen antagonists in uterine myometrial cells and suggest that this class of compounds may be effective for treatment of this important gynecologic neoplasm.

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S HirataJ Kato
Feb 1, 1992·American Journal of Obstetrics and Gynecology·G D Adamson
Oct 1, 1990·American Journal of Clinical Pathology·S F Cramer, A Patel
Jun 12, 1995·Annals of the New York Academy of Sciences·R Fuchs-YoungH U Bryant
Apr 1, 1995·Biology of Reproduction·K B PorterW N Spellacy
Mar 1, 1995·Obstetrics and Gynecology·D D BradhamC D Thompson
Nov 1, 1994·International Journal of Cancer. Journal International Du Cancer·L T van der VenW den Otter
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·R S YeungA G Knudson
Sep 1, 1993·Postgraduate Medicine·Janet K Christiansen

❮ Previous
Next ❯

Citations

Jan 9, 2004·Fertility and Sterility·Stefan JirecekRene Wenzl
Mar 17, 1999·American Journal of Obstetrics and Gynecology·C P SpencerJ M Rymer
Jul 5, 2001·Fertility and Sterility·S PalombaC Nappi
Jun 1, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·O SadanH Zakut
Oct 19, 2002·Molecular and Cellular Endocrinology·Leslie C HodgesCheryl L Walker
May 28, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Yuhua Z Farnell, Nancy H Ing
Feb 13, 2001·Primary Care Update for Ob/Gyns·M J. Sexton, R B. Gherman
Jun 27, 2003·Environmental Health Perspectives·Gordon P FlakeDarlene Dixon
Dec 17, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A DarbhamullaB Benatar
Mar 7, 2008·Expert Opinion on Emerging Drugs·Ming-Huei Cheng, Peng-Hui Wang
Mar 1, 2006·Obstetrics and Gynecology Clinics of North America·Erica E Marsh, Serdar E Bulun
Feb 19, 1999·Baillière's Clinical Obstetrics and Gynaecology·T Eldar-Geva, D L Healy
Aug 25, 2016·Fertility and Sterility·Tiffany A KatzAyman Al-Hendy
Jan 22, 2000·Veterinary Pathology·K M WhitneyD H Schlafer
Feb 24, 2001·Toxicologic Pathology·K D HoustonC L Walker
Mar 23, 2011·Reproductive Sciences·Lin-Hung WeiChi-An Chen
Dec 26, 2001·Carcinogenesis·C L WalkerB Davis
Oct 21, 2003·Genes, Chromosomes & Cancer·Cheryl Lyn WalkerJeffery I Everitt
Apr 4, 2018·Menopause : the Journal of the North American Menopause Society·Vedhapriya Srinivasan, Mark G Martens
Nov 11, 1999·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A EvansD Healy
Jul 13, 2000·Obstetrical & Gynecological Survey·V L BakerR B Jaffe
Jul 4, 2013·Molecular Endocrinology·Hen PrizantStephen R Hammes
Apr 21, 2001·Cardiovascular Drug Reviews·A SaittaF Squadrito
Jan 13, 2016·Clinical Obstetrics and Gynecology·Chantal B BartelsJames H Segars
Sep 10, 2020·Biology of Reproduction·Sneh M Toprani, Varsha Kelkar Mane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.