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Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model

Experimental Neurology

Nov 14, 2019

Yvonne MünsterArne Herring

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Abstract

We recently identified excessive cerebral kallikrein-8 (KLK8) mRNA and protein levels at incipient stages of Alzheimer's disease (AD) in AD patients and TgCRND8 mice. Additionally, we showed that antibody-mediated KLK8 inhibition exerts therapeutic effects on AD along with enhancing neu...read more

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Alzheimer's Disease
Brain
Hippocampus (Brain)
Laboratory mice
Mice, Transgenic
Neuronal Plasticity
Neurons
Phosphorylation
RNA, Messenger
Tau Proteins
2
1
4
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Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model

Experimental Neurology

Nov 14, 2019

Yvonne MünsterArne Herring

PMID: 31734318

DOI: 10.1016/j.expneurol.2019.113115

Abstract

We recently identified excessive cerebral kallikrein-8 (KLK8) mRNA and protein levels at incipient stages of Alzheimer's disease (AD) in AD patients and TgCRND8 mice. Additionally, we showed that antibody-mediated KLK8 inhibition exerts therapeutic effects on AD along with enhancing neu...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Hippocampus (Brain)
Laboratory mice
Mice, Transgenic
2
1
4

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