PMID: 4596403Apr 13, 1974

Inhibition of experimental asthma in man by a new drug (AH 7725) active when given by mouth

British Medical Journal
E S AssemM K McAllen

Abstract

A new drug, AH 7725, with properties similar to those of disodium cromoglycate (Intal) has the additional feature of being effective when taken by mouth. Six patients with allergic asthma were studied by bronchial challenge tests with antigen. In every one the drug was found to inhibit (either partially or completely) the immediate-type asthmatic response. Late responses were not influenced. The results were significant at the 0.5% level.These findings suggest that AH 7725 given by mouth may be able to inhibit naturally occurring asthmatic attacks in allergic patients. In this case its particular advantage as a prophylactic drug would lie in the treatment of very young asthmatic children and other patients who cannot take drugs by inhalation.

References

Jan 1, 1973·International Archives of Allergy and Applied Immunology·E S Assem
Jun 1, 1973·Clinical Allergy·E S Assem, M K McAllen
Jan 1, 1973·International Archives of Allergy and Applied Immunology·J FullartonC Vardey
Jan 1, 1973·International Archives of Allergy and Applied Immunology·E S Assem, M K McAllen
Jun 23, 1951·Lancet·H HERXHEIMER

Citations

Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Apr 1, 1981·Agents and Actions·R G Alvarez, W Kazimierczak
Apr 3, 1976·British Medical Journal·J C Foreman, L G Garland
Aug 1, 1979·Current Problems in Pediatrics·S C SiegelR M Katz
Jan 1, 1981·British Journal of Diseases of the Chest·T C Stokes, J Morley
Jun 1, 1976·Acta Allergologica·R PauwelsM van der Straeten
Oct 18, 1974·Nature·B J BroughtonD R Maxwell
Sep 1, 1976·Clinical Allergy·R PauwelsM van der Straeten
Sep 1, 1976·Clinical Allergy·R PauwelsM van der Straeten

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