PMID: 15387371Sep 25, 2004Paper

Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice

Clinical & Experimental Metastasis
Makiya NishikawaMitsuru Hashida

Abstract

Bovine liver catalase derivatives possessing diverse tissue distribution properties were synthesized, and their effects on hepatic metastasis of colon carcinoma cells were examined in mice. An intraportal injection of 1 x 10(5) colon 26 cells resulted in the formation of more than 50 metastatic colonies on the surface of the liver at 14 days after injection. An intravenous injection of catalase (CAT; 35000 units/kg of body weight) significantly (P < 0.001) reduced the number of the colonies in the liver. Galactosylated (Gal-), mannosylated (Man-) and succinylated (Suc-) CAT were also tested in the same system. Of these derivatives, Gal-CAT showed the greatest inhibitory effect on hepatic metastasis, and the number of colonies was significantly (P < 0.001) smaller than following treatment with catalase. High activities of matrix metalloproteinases (MMPs), especially MMP-9, were detected in the liver of mice bearing metastatic tumor tissues, which was significantly (P < 0.05) reduced by Gal-CAT. These results, combined with our previous finding that Gal-CAT can be efficiently delivered to hepatocytes, indicate that the targeted delivery of catalase to the liver by galactosylation is a promising approach to suppress hepatic metast...Continue Reading

Citations

Jun 11, 2009·Annals of Biomedical Engineering·Michael J Heffernan, Niren Murthy
Nov 7, 2006·Clinical & Experimental Metastasis·Kenji HyoudouMitsuru Hashida
Mar 22, 2008·Clinical & Experimental Metastasis·Kenji HyoudouMitsuru Hashida
Jun 28, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Andrea Azcárate-PerilJosé M Bruno-Bárcena
Dec 31, 2010·Respiratory Research·Nao OdajimaMasaharu Nishimura
Feb 3, 2005·Biological & Pharmaceutical Bulletin·Makiya Nishikawa
Mar 13, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Abdullah OnulJames A Radosevich
Nov 15, 2011·Annual Review of Pathology·Federica SotgiaMichael P Lisanti
Apr 28, 2006·Expert Opinion on Drug Delivery·Makiya Nishikawa, Mitsuru Hashida
Dec 21, 2010·Journal of Biotechnology·Jean Guy LeBlancAlejandra de Moreno de LeBlanc
Nov 26, 2015·Free Radical Biology & Medicine·Filipe Vilas-BoasCarla Real
Oct 23, 2014·Journal of Cancer Prevention·Ji Ye LimYuri Kim
Apr 14, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kenji HyoudouMitsuru Hashida
Apr 23, 2009·Advanced Drug Delivery Reviews·Makiya NishikawaYoshinobu Takakura
Jul 27, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kenji HyoudouMitsuru Hashida
Mar 27, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kenji HyoudouMitsuru Hashida
Oct 7, 2006·Free Radical Biology & Medicine·Kenji HyoudouMitsuru Hashida
Nov 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Makiya NishikawaMitsuru Hashida
Sep 21, 2006·Redox Report : Communications in Free Radical Research·Lin LiWeida Huang
Jun 15, 2011·Free Radical Biology & Medicine·Chika NishizakiYoshinobu Takakura
Nov 23, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Seong Myung, Young Eun Joo
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Jan 11, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·M ZienkiewiczJ Sá
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenji HyoudouMitsuru Hashida

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