PMID: 7513024Nov 1, 1993Paper

Inhibition of fertility in female mice by immunization with a B-cell epitope, the synthetic sperm peptide, P10G

Journal of Reproductive Immunology
M G O'RandK S Tung

Abstract

Human patient sera containing antisperm antibodies (from vasectomized men and infertile women) immunologically react with the synthetic peptide P10G (PGGGTLPPSG), and affinity purified antibodies to P10G (anti-P10G) react with human spermatozoa (O'Rand et al., 1990). In this study P10G was used to elicit antibodies and the effect of the antibodies on fertility in female mice determined. The P10G sequence is derived from the 14-kDa rabbit sperm autoantigen, RSA (O'Rand and Widgren, 1990). The results of this study demonstrate that female mice can become infertile when immunized with the synthetic peptide P10G conjugated to the carrier protein keyhole limpet hemocyanin (KLH). However, the results also show that it is important to distinguish those mice with high serum antibody levels from those with lower levels. Infertility was clearly apparent in the high titer subgroup with an 80% decrease in pregnancy rate during the last of three matings and a 71% decrease in litter size over all three matings when compared to the low titer subgroup or the control groups. Significantly, mice immunized with P10G without carrier protein show no detectable antigen specific proliferation of lymph node cells in response to 100 microM of the pepti...Continue Reading

References

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Citations

Feb 12, 1998·Journal of Reproductive Immunology·M G O'Rand, I A Lea
Jul 7, 1999·Journal of Reproductive Immunology·J Frayne, L Hall
Mar 1, 1996·American Journal of Reproductive Immunology : AJRI·J C Herr
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·A B Diekman, J C Herr
Jan 16, 2015·Advanced Biomedical Research·Seema LekhwaniRagini Singh
Jan 20, 2016·American Journal of Reproductive Immunology : AJRI·Feng XueChen Xu
Oct 27, 2009·Journal of Reproductive Immunology·Rajesh K Naz
Dec 18, 2008·American Journal of Reproductive Immunology : AJRI·Rajesh K Naz
Apr 13, 2011·American Journal of Reproductive Immunology : AJRI·Rajesh K Naz
Apr 23, 2015·Journal of Reproductive Immunology·Angireddy Rajesh, Suresh Yenugu
Aug 22, 2012·Human Vaccines & Immunotherapeutics·Justyna BazanAndrzej Gamian
Dec 7, 2013·Expert Review of Vaccines·Rajesh K Naz
Nov 1, 1995·Andrologia·E Töpfer-PetersenF Sinowatz

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