Inhibition of filamentous fungi by ketoconazole-functionalized electrospun nanofibers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Flávio Fonseca VerasAdriano Brandelli

Abstract

Nanotechnology strategies have been used for delivery and controlled release of antimicrobial drugs. Electrospun nanofibers can be versatile vehicles to incorporate antimicrobials. In this work, poly-ε-caprolactone nanofibers functionalized with ketoconazole were produced by electrospinning and tested against filamentous fungi. Ketoconazole-free nanofibers were produced as controls. Functionalized nanofibers showed antifungal activity against Aspergillus flavus, A. carbonarius, A. niger, Aspergillus sp. A29, Fusarium oxysporum and Penicillium citrinum by agar diffusion test. Inhibitory zones ranging from 6 to 44mm were observed, this larger inhibition was against A. flavus. The nanofibers were incubated in different simulant solutions to evaluate the ketoconazole release, which was only detected in the solution containing 5% (v/v) Tween 20. Electron microscopy images showed the nanofibers with ketoconazole presented mean diameters of 526nm, and the degradation of the nanofiber structures could be observed by electron microscopy after incubation in simulant solution. Infrared and thermal analyses indicated that ketoconazole was dispersed without chemical interactions with the polycaprolactone matrix. These results suggest that p...Continue Reading

References

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Apr 20, 2012·Mini Reviews in Medicinal Chemistry·A Brandelli
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Sep 2, 2015·International Journal of Pharmaceutics·Shilpa KakkarIndu Pal Kaur

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Citations

Apr 4, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Panoraia I SiafakaDimitrios N Bikiaris
Mar 2, 2016·International Journal of Molecular Sciences·Panoraia I SiafakaDimitrios N Bikiaris
May 16, 2018·Experimental Biology and Medicine·Agnes B MeirelesLibardo A González-Torres
May 13, 2020·Drug Development and Industrial Pharmacy·Fatmanur Tuğcu-DemirözFüsun Acartürk
Dec 22, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Panna VassZsombor K Nagy
Nov 30, 2018·Macromolecular Bioscience·Rahimeh RasouliAlain Dufresne

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